dc.contributor.authors |
Tanyeli, Ayhan; Erdogan, Derya Guzel; Comakli, Selim; Polat, Elif; Guler, Mustafa Can; Eraslan, Ersen; Doganay, Songul |
|
dc.date.accessioned |
2022-12-20T13:25:14Z |
|
dc.date.available |
2022-12-20T13:25:14Z |
|
dc.date.issued |
2022 |
|
dc.identifier.issn |
1052-0295 |
|
dc.identifier.uri |
http://dx.doi.org/10.1080/10520295.2022.2036368 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12619/99257 |
|
dc.description |
Bu yayının lisans anlaşması koşulları tam metin açık erişimine izin vermemektedir. |
|
dc.description.abstract |
Ovarian ischemia-reperfusion (I-R) injury may damage remote organs, including the lungs. We investigated whether apocynin, a NADPH oxidase inhibitor, might protect against ovarian I-R induced apoptosis in the lungs of rats. Bilateral ovarian I-R was induced for 3 h, then apocynin was applied at two concentrations. Lung tissue was evaluated using spectrophotometric and immunohistochemical methods. We found that I-R increased total oxidant status (TOS), oxidative stress index (OSI) and myeloperoxidase (MPO) levels, and immunostaining of nuclear factor kappa-B (NF-kappa B), light chain 3B (LC3B), interleukin 1-beta (IL-1 beta), caspase-3 and tumor necrosis factor-alpha (TNF-alpha), but decreased superoxide dismutase (SOD) values. Apocynin application to I-R injured rats enhanced recovery of lung tissue oxidants and improved both histology and frequency of apoptosis. |
|
dc.language |
English |
|
dc.language.iso |
eng |
|
dc.relation.isversionof |
10.1080/10520295.2022.2036368 |
|
dc.subject |
Biotechnology & Applied Microbiology |
|
dc.subject |
Cell Biology |
|
dc.subject |
Apocynin |
|
dc.subject |
apoptosis |
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dc.subject |
ischemia |
|
dc.subject |
lung injury |
|
dc.subject |
oxidative damage |
|
dc.title |
Therapeutic effects of apocynin on ovarian ischemia-reperfusion induced lung injury |
|
dc.contributor.authorID |
Guler, Mustafa Can/0000-0001-8588-1035 |
|
dc.identifier.volume |
97 |
|
dc.identifier.startpage |
536 |
|
dc.identifier.endpage |
545 |
|
dc.relation.journal |
BIOTECHNIC & HISTOCHEMISTRY |
|
dc.identifier.issue |
7 |
|
dc.identifier.doi |
10.1080/10520295.2022.2036368 |
|
dc.identifier.eissn |
1473-7760 |
|
dc.contributor.author |
Tanyeli, Ayhan |
|
dc.contributor.author |
Erdogan, Derya Guzel |
|
dc.contributor.author |
Comakli, Selim |
|
dc.contributor.author |
Polat, Elif |
|
dc.contributor.author |
Guler, Mustafa Can |
|
dc.contributor.author |
Eraslan, Ersen |
|
dc.contributor.author |
Doganay, Songul |
|
dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
|