A novel 2-dimensional nanocomposite as a mediator for the determination of doxorubicin in biological samples

Mehmandoust, Mohammad; Khoshnavaz, Yasamin; Karimi, Fatemeh; Cakar, Soner; Ozacar, Mahmut; Erk, Nevin

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dc.contributor.authors	Mehmandoust, Mohammad; Khoshnavaz, Yasamin; Karimi, Fatemeh; Cakar, Soner; Ozacar, Mahmut; Erk, Nevin
dc.date.accessioned	2022-12-20T13:25:10Z
dc.date.available	2022-12-20T13:25:10Z
dc.date.issued	2022
dc.identifier.issn	0013-9351
dc.identifier.uri	http://dx.doi.org/10.1016/j.envres.2022.113590
dc.identifier.uri	https://hdl.handle.net/20.500.12619/99223
dc.description	Bu yayının lisans anlaşması koşulları tam metin açık erişimine izin vermemektedir.
dc.description.abstract	In our study, the electrochemical properties of a novel activated nanocomposite were studied with 2-dimensional graphitic carbon nitride/sodium dodecyl sulfate/graphene nanoplatelets on the screen-printed electrodes (2D-gC3N4/SDS/GNPs/SPE). The as-fabricated sensor exhibited excellent electrochemical performance, including wide dynamic ranges from 0.03 to 1.0 and 1.0-13.5 mu M with a low limit of detection (LOD) of 10.0 nM. The fabricated 2D-g-C3N4/SDS/GNPs/SPE electrode exhibited high sensitivity, stability, good reproducibility, reusability, and repeatability towards DOX sensing. It can be utilized in real samples, including human plasma and urine, with excellent correlations and coefficients of variation below 6.0%. Therefore, this study presents potential application values in sensing DOX with efficient performance. Finally, the accuracy was attested by comparison with high-performance liquid chromatography (HPLC) as the reference method, signalizing a good agreement.
dc.language	English
dc.language.iso	eng
dc.relation.isversionof	10.1016/j.envres.2022.113590
dc.subject	Environmental Sciences & Ecology
dc.subject	Public, Environmental & Occupational Health
dc.subject	Doxorubicin monitoring
dc.subject	Graphitic carbon nitride
dc.subject	Graphene nanoplatelets
dc.subject	Biological sample
dc.title	A novel 2-dimensional nanocomposite as a mediator for the determination of doxorubicin in biological samples
dc.contributor.authorID	Mehmandoust, Mohammad/0000-0002-8545-0603
dc.identifier.volume	213
dc.relation.journal	ENVIRONMENTAL RESEARCH
dc.identifier.doi	10.1016/j.envres.2022.113590
dc.identifier.eissn	1096-0953
dc.contributor.author	Mehmandoust, Mohammad
dc.contributor.author	Khoshnavaz, Yasamin
dc.contributor.author	Karimi, Fatemeh
dc.contributor.author	Cakar, Soner
dc.contributor.author	Ozacar, Mahmut
dc.contributor.author	Erk, Nevin
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı