dc.contributor.authors |
Ozkul, Bahattin; Ozkul, Ozlem; Bilir, Cemil |
|
dc.date.accessioned |
2022-12-20T13:25:07Z |
|
dc.date.available |
2022-12-20T13:25:07Z |
|
dc.date.issued |
2022 |
|
dc.identifier.issn |
1573-4056 |
|
dc.identifier.uri |
http://dx.doi.org/10.2174/1573405618666220303105410 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12619/99201 |
|
dc.description |
Bu yayının lisans anlaşması koşulları tam metin açık erişimine izin vermemektedir. |
|
dc.description.abstract |
Background: Pancreatic cancer is mostly diagnosed in advanced stages, and treatment results are not satisfactory. L3 skeletal muscle index (SMI) has emerged as a prognostic factor in pancreatic cancer patients. We aimed to assess the association between sarcopenia and overall survival in patients with pancreatic cancer in this study. Methods: Patients who were admitted to the Department of Oncology between March 2012 and December 2019 and diagnosed with pancreatic cancer were evaluated. The computerized tomography images and laboratory parameters of a total of 115 patients were included in this retrospective single-center study. We defined sarcopenia as an SMI <43,56 cm(2)/m(2) for females and <56,44 cm(2)/m(2) for males using the receiver operating characteristics (ROC) curve in the study population. Univariate and multivariate analyses were performed by using Cox-regression modelling, and survival curves were constructed by using Kaplan-Meier method. Results: 70% of the patients were male, and the mean age was 64.9 +/- 9.9 years (mean +/- SD). 70.6% of female patients and 67.9% of male patients were diagnosed with stage 4 cancer. The prevalence of sarcopenia in the whole patient group was 29.6%. By multivariate analysis, SMI (p=0.009) and advanced stage (p=0.003) were found as poor prognostic factors for overall survival (OS). The neutrophil to lymphocyte ratio (NLR) was statistically significantly higher in sarcopenic patients than in non-sarcopenic patients (p=0.031). Conclusion: Patients having sarcopenia at the time of diagnosis may demonstrate poorer overall survival of pancreatic cancer, and SMI may be considered as a potential prognostic factor. |
|
dc.language |
English |
|
dc.language.iso |
eng |
|
dc.relation.isversionof |
10.2174/1573405618666220303105410 |
|
dc.subject |
Radiology, Nuclear Medicine & Medical Imaging |
|
dc.subject |
Cancer |
|
dc.subject |
computed tomography |
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dc.subject |
overall survival |
|
dc.subject |
pancreas |
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dc.subject |
sarcopenia |
|
dc.title |
Predicting the Overall Survival in Patients with Advanced Pancreatic Cancer by Calculating L3 Skeletal Muscle Index Derived from CT |
|
dc.contributor.authorID |
Bilir, Cemil/0000-0002-1372-4791 |
|
dc.identifier.volume |
18 |
|
dc.identifier.startpage |
1079 |
|
dc.identifier.endpage |
1085 |
|
dc.relation.journal |
CURRENT MEDICAL IMAGING |
|
dc.identifier.issue |
10 |
|
dc.identifier.doi |
10.2174/1573405618666220303105410 |
|
dc.identifier.eissn |
1875-6603 |
|
dc.contributor.author |
Ozkul, Bahattin |
|
dc.contributor.author |
Ozkul, Ozlem |
|
dc.contributor.author |
Bilir, Cemil |
|
dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
|