dc.contributor.authors |
Bostanci, Mehmet Suhha; Budak, Ozcan; Cakiroglu, Huseyin; Kose, Osman; Erdogan, Mehtap; Yuvaci, Hilal Uslu; Cokluk, Erdem |
|
dc.date.accessioned |
2022-12-20T13:24:51Z |
|
dc.date.available |
2022-12-20T13:24:51Z |
|
dc.date.issued |
2022 |
|
dc.identifier.issn |
1933-7191 |
|
dc.identifier.uri |
http://dx.doi.org/10.1007/s43032-022-01132-5 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12619/99048 |
|
dc.description |
Bu yayının lisans anlaşması koşulları tam metin açık erişimine izin vermemektedir. |
|
dc.description.abstract |
Local ischemic damage resulting from ovarian torsion is a common cause of decreased follicular activity and infertility. It was aimed to evaluate the effect of granulocyte colony-stimulating factor (G-CSF) protection on in vitro fertilization (IVF) results against experimental ischemic (I) and ischemic-reperfusion (I/R) injury in rat ovaries. The study consisted of 35 adult female Sprague-Dawley albino rats (sham, ischemia, I/R, I + G-CSF, and I/R + G-CSF) randomly assigned to 5 groups, each containing 7 rats. While bilateral adnexal torsion was applied to the ischemia groups for 3 h, detorsion was applied to the reperfusion groups. Intraperitoneal 100 IU/kg G-CSF was administered 30 min prior to ischemia (I + G-CSF) or reperfusion (I/R + G-CSF). After ovulation induction (intraperitoneal 150-300 IU/kg PMSG), the oocytes were collected and IVF was applied. Statistically significant differences were observed between the collected oocyte numbers in I and I + G-CSF, I/R, and I/R + G-CSF groups (P values were P = 0.001 for the I-I + G-SCF groups and P = 0.003 for I/R-IR + G-CSF, respectively). An increase in the number of MII oocytes obtained was observed in the I + G-CSF and I/R + G-CSF groups compared to the I and I/R groups. Grade 1 and grade 2 embryo numbers were statically different between the I/R and I/R + G-CSF groups (P values were P = 0.023 for grade 1 embryos and P = 0.045 for grade 2 embryos, respectively). G-CSF treatment was found to be effective in reducing I- and I/R-induced ovarian damage. |
|
dc.language |
English |
|
dc.language.iso |
eng |
|
dc.relation.isversionof |
10.1007/s43032-022-01132-5 |
|
dc.subject |
Obstetrics & Gynecology |
|
dc.subject |
Reproductive Biology |
|
dc.subject |
Ischemia |
|
dc.subject |
reperfusion injury |
|
dc.subject |
Ovarian torsion |
|
dc.subject |
Granulocyte colony-stimulating factor |
|
dc.subject |
In vitro fertilization |
|
dc.title |
The Effectiveness of Granulocyte Colony-Stimulating Factor (G-CSF) Against Experimental Ischemia-Reperfusion Injury in Rat Ovaries and Its Effect on In Vitro Fertilization Outcomes |
|
dc.type |
Early Access |
|
dc.contributor.authorID |
bostanci, mehmet suhha/0000-0002-4776-6244 |
|
dc.contributor.authorID |
ERDOGAN, Mehtap/0000-0002-5422-5091 |
|
dc.contributor.authorID |
Cakiroglu, Huseyin/0000-0002-3445-6060 |
|
dc.contributor.authorID |
, erdem/0000-0002-6205-5109 |
|
dc.relation.journal |
REPRODUCTIVE SCIENCES |
|
dc.identifier.doi |
10.1007/s43032-022-01132-5 |
|
dc.identifier.eissn |
1933-7205 |
|
dc.contributor.author |
Bostanci, Mehmet Suhha |
|
dc.contributor.author |
Budak, Ozcan |
|
dc.contributor.author |
Cakiroglu, Huseyin |
|
dc.contributor.author |
Kose, Osman |
|
dc.contributor.author |
Erdogan, Mehtap |
|
dc.contributor.author |
Yuvaci, Hilal Uslu |
|
dc.contributor.author |
Cokluk, Erdem |
|
dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
|