dc.contributor.authors |
Ozkan, Asuman Deveci; Alimudin, Janiah; Kilciler, Yasemin; Yuksel, Burcu; Aksoy, Ozlem; Betts, Zeynep |
|
dc.date.accessioned |
2022-12-20T13:24:50Z |
|
dc.date.available |
2022-12-20T13:24:50Z |
|
dc.date.issued |
2022 |
|
dc.identifier.issn |
0960-3123 |
|
dc.identifier.uri |
http://dx.doi.org/10.1080/09603123.2022.2120970 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12619/99044 |
|
dc.description |
Bu yayının lisans anlaşması koşulları tam metin açık erişimine izin vermemektedir. |
|
dc.description.abstract |
Developing new drugs from natural products is important for therapeutic effects to minimise tissue toxicity of drugs used in cancer treatment. Eisenia foetida is a worm with a double transport system consisting of coelomic fluid (ECF) that can be used as alternative medicine. It is important to eliminate or reduce the high cytotoxicity of sodium butyrate (NaBu), a chemotherapeutic agent used in breast cancer treatment, for both neoplastic and normal cells. We aimed to evaluate the effect of ECF on the oxidative toxicity induced by NaBu in MCF-7 cells, changes in ROS production levels and expression of cell death and ROS-related genes. It was determined that the expression levels of Bax and Bcl-2 genes remained unchanged, while the amount of ROS decreased significantly in MCF-7 cells exposed to NaBu with ECF. Thus, ECF may be a potential therapeutic molecule with fewer side effects in cancer treatment in the future. |
|
dc.language |
English |
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dc.language.iso |
eng |
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dc.relation.isversionof |
10.1080/09603123.2022.2120970 |
|
dc.subject |
Environmental Sciences & Ecology |
|
dc.subject |
Public, Environmental & Occupational Health |
|
dc.subject |
Breast cancer |
|
dc.subject |
chemo-protective effect |
|
dc.subject |
Eisenia foetida |
|
dc.subject |
ROS |
|
dc.title |
In vitro chemo-protective effect of Eisenia foetida coelomic fluid against histone deacetylase inhibitor-induced oxidative toxicity in breast cancer cells |
|
dc.type |
Early Access |
|
dc.contributor.authorID |
Deveci Ozkan, Asuman/0000-0002-3248-4279 |
|
dc.contributor.authorID |
Betts, Zeynep/0000-0003-2391-7543 |
|
dc.contributor.authorID |
Alimudin, Janiah/0000-0001-8946-5397 |
|
dc.relation.journal |
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH |
|
dc.identifier.doi |
10.1080/09603123.2022.2120970 |
|
dc.identifier.eissn |
1369-1619 |
|
dc.contributor.author |
Ozkan, Asuman Deveci |
|
dc.contributor.author |
Alimudin, Janiah |
|
dc.contributor.author |
Kilciler, Yasemin |
|
dc.contributor.author |
Yuksel, Burcu |
|
dc.contributor.author |
Aksoy, Ozlem |
|
dc.contributor.author |
Betts, Zeynep |
|
dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
|