dc.contributor.authors |
Resen, Ali K.; Atiroglu, Atheer; Atiroglu, Vesen; Eskiler, Gamze Guney; Aziz, Ismail H.; Kaleli, Suleyman; Ozacar, Mahmut |
|
dc.date.accessioned |
2022-12-20T13:24:48Z |
|
dc.date.available |
2022-12-20T13:24:48Z |
|
dc.date.issued |
2022 |
|
dc.identifier.issn |
0141-8130 |
|
dc.identifier.uri |
http://dx.doi.org/10.1016/j.ijbiomac.2021.12.130 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12619/99019 |
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dc.description |
Bu yayının lisans anlaşması koşulları tam metin açık erişimine izin vermemektedir. |
|
dc.description.abstract |
This study was planned to evolve the bioavailability and therapeutic efficiency of Gemcitabine (GEM) and 5Fluorouracil with decreased side effects using MIL-100 nano-composite as carrier. Impregnation approach was used for encapsulation of 5-Fluorouracil alone and with GEM inside the MIL-100. The formed 5-Fluorouracil@MIL-100 and 5-Fluorouracil-GEM@MIL-100 were then coated with chitosan, sequentially chelated with iron(III) and conjugated with quercetin, eventually obtaining a multifunctional MIL-100 nanocarrier. The hybrid nano carrier nascency was verified by different characterization results. pH-sensitive releases of 5-Fluorouracil and GEM were observed because of the inherent pH-dependent stability of MIL-100. Additionally, we evaluated the anti-cancer activity of these nanocarriers through WST-1 analysis and acridine orange staining in MCF-7 human breast cancer and HUVEC control cell lines. Our findings showed that all nanocarriers exhibited anti-cancer activity and induced apoptosis in MCF-7 cells. However, 5-Fluorouracil@MIL-100 and chitosan-coated 5-Fluorouracil@MIL-100 with quercetin were more effective than other nanocarriers in MCF-7 cells (p < 0.05). Moreover, we observed cytotoxicity in HUVEC cells due to the adverse side effects of chemotherapy drugs. However, chitosan coated nanocarriers with quercetin were less toxic on HUVEC cells at particularly 1 mu g/mL. Therefore, MIL-100 could be used for a promising chemotherapeutic drugs delivery and chitosan coated drugs with quercetin could be useful for reducing toxicity on normal cells. |
|
dc.language |
English |
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dc.language.iso |
eng |
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dc.relation.isversionof |
10.1016/j.ijbiomac.2021.12.130 |
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dc.subject |
Biochemistry & Molecular Biology |
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dc.subject |
Chemistry |
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dc.subject |
Polymer Science |
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dc.subject |
MIL-100 |
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dc.subject |
Drug delivery system |
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dc.subject |
5-Fluorouracil |
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dc.subject |
Gemcitabine |
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dc.subject |
Breast cancer |
|
dc.title |
Effectiveness of 5-Fluorouracil and gemcitabine hydrochloride loaded iron-based chitosan-coated MIL-100 composite as an advanced, biocompatible, pH-sensitive and smart drug delivery system on breast cancer therapy |
|
dc.contributor.authorID |
ATiROĞLU, Vesen/0000-0001-7551-133X |
|
dc.contributor.authorID |
Kaleli, Suleyman/0000-0002-6043-2521 |
|
dc.contributor.authorID |
Aziz, Ismail H/0000-0003-0263-3357 |
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dc.identifier.volume |
198 |
|
dc.identifier.startpage |
175 |
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dc.identifier.endpage |
186 |
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dc.relation.journal |
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES |
|
dc.identifier.doi |
10.1016/j.ijbiomac.2021.12.130 |
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dc.identifier.eissn |
1879-0003 |
|
dc.contributor.author |
Resen, Ali K. |
|
dc.contributor.author |
Atiroglu, Atheer |
|
dc.contributor.author |
Atiroglu, Vesen |
|
dc.contributor.author |
Eskiler, Gamze Guney |
|
dc.contributor.author |
Aziz, Ismail H. |
|
dc.contributor.author |
Kaleli, Suleyman |
|
dc.contributor.author |
Ozacar, Mahmut |
|
dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
|