Protective effect of Eisenia foetida coelomic fluid against oxidative damage in human endothelial cells

Abstract

The protective effect of Eisenia foetida coelomic fluid on hydrogen peroxide-induced oxidative damage and cell death was determined at gene and protein levels. The coelomic fluid protects viability and cell morphology in human umbilical vein endothelial cells, and decreases reactive oxygen species production and apoptotic cells and increases anti-oxidative gene and protein expressions. Eisenia foetida coelomic fluid is potentially a therapeutic candidate for drug development.