dc.contributor.authors |
Bostanci, Mehmet Suhha; Budak, Ozcan; Cakiroglu, Huseyin; Gok, Koray; Kose, Osman; Cokluk, Erdem |
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dc.date.accessioned |
2022-12-20T13:24:45Z |
|
dc.date.available |
2022-12-20T13:24:45Z |
|
dc.date.issued |
2022 |
|
dc.identifier.issn |
1341-8076 |
|
dc.identifier.uri |
http://dx.doi.org/10.1111/jog.15232 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12619/98963 |
|
dc.description |
Bu yayının lisans anlaşması koşulları tam metin açık erişimine izin vermemektedir. |
|
dc.description.abstract |
Objective Ovarian torsion is a common cause of local ischemic damage, reduced follicular activity and infertility. This study aimed to investigate how well platelet-rich plasma (PRP) protects against experimental ischemic (I) and ischemia-reperfusion (I/R) injury in rat ovaries and its effect on in vitro fertilization (IVF) outcomes. Method Fifty-six adult female Sprague-Dawley albino rats were randomly assigned to six groups of eight animals each: Sham, Ischemia, I/R, Sham + PRP, I + PRP, and I/R + PRP. The remaining eight animals were used to prepare the PRP. The ischemia groups were subjected to bilateral adnexal torsion for 3 h, while the I/R and I/R + PRP groups received subsequent detorsion for 3 h. Intraperitoneal (i.p.) PRP was administered 30 min prior to ischemia (I + PRP) or reperfusion (I/R + PRP). The ovaries were stimulated through an intraperitoneal injection of 150-300 internal units of IU/kg PMSG. After ovulation induction, oocytes were taken from the ovaries, and IVF was performed. Results The number of MII oocytes reached the highest number with 4.63 +/- 0.74 in the S group and had the lowest number with 0.50 +/- 0.53 in the I/R group. There were statistically significant differences for the number of embryos obtained on the second day between the I and I + PRP groups and the I/R and I/R + PRP groups (p = 0.000). In comparing anti-Mullerian hormone 1 (AMH1) and AMH2 values within the group, the highest decrease was observed in the I and I/R groups. Conclusion PRP is effective in minimizing ovarian damage and preserving ovarian reserves following ovarian torsion. |
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dc.language |
English |
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dc.language.iso |
eng |
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dc.relation.isversionof |
10.1111/jog.15232 |
|
dc.subject |
Obstetrics & Gynecology |
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dc.subject |
in vitro fertilization |
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dc.subject |
ischemia-reperfusion injury |
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dc.subject |
ovarian torsion |
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dc.subject |
platelet-rich plasma |
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dc.subject |
PRP |
|
dc.title |
The effect of protection of platelet-rich plasma against experimental ischemia/reperfusion injury in the rat ovary on in vitro fertilization outcomes |
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dc.contributor.authorID |
Bostanci, Mehmet Sühha/0000-0002-4776-6244 |
|
dc.contributor.authorID |
cokluk, erdem/0000-0002-6205-5109 |
|
dc.contributor.authorID |
kose, osman/0000-0001-5656-6853 |
|
dc.contributor.authorID |
Cakiroglu, Huseyin/0000-0002-3445-6060 |
|
dc.identifier.volume |
48 |
|
dc.identifier.startpage |
1390 |
|
dc.identifier.endpage |
1398 |
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dc.relation.journal |
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH |
|
dc.identifier.issue |
6 |
|
dc.identifier.doi |
10.1111/jog.15232 |
|
dc.identifier.eissn |
1447-0756 |
|
dc.contributor.author |
Bostanci, Mehmet Suhha |
|
dc.contributor.author |
Budak, Ozcan |
|
dc.contributor.author |
Cakiroglu, Huseyin |
|
dc.contributor.author |
Gok, Koray |
|
dc.contributor.author |
Kose, Osman |
|
dc.contributor.author |
Cokluk, Erdem |
|
dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
|