dc.date.accessioned |
2021-06-08T09:11:55Z |
|
dc.date.available |
2021-06-08T09:11:55Z |
|
dc.date.issued |
2020 |
|
dc.identifier.issn |
1088-4246 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12619/96140 |
|
dc.description |
Bu yayının lisans anlaşması koşulları tam metin açık erişimine izin vermemektedir. |
|
dc.description.abstract |
The preparation and assessment of carbonic anhydrase and paraoxonase enzyme inhibition properties of 3-(2-(5-amino-4-(4-bromophenyl)-3-methyl-1H-pyrazol-1-yl)ethoxy)phthalonitrile (2) and its nitrogen-containing non-peripheral phthalocyanine derivatives (3 and 4) are reported for the first time. The new phthalonitrile and its phthalocyanine derivatives have been elucidated by FT-IR spectroscopy, H-1-NMR, C-13-NMR, mass and UV-vis spectroscopy. The results demonstrated that all synthesized compounds moderately inhibited carbonic anhydrase and paraoxonase enzymes. Among the compounds, the most active ones were found to be compound 4 for PON (Ki : 0.14 mu M), compound 3 for hCA I (Ki : 22.52 mu M) and compound 1 for hCA 11 (Ki : 13.62 mu M). |
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dc.language |
English |
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dc.language.iso |
eng |
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dc.publisher |
WORLD SCI PUBL CO INC |
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dc.relation.isversionof |
10.1142/S1088424620500170 |
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dc.rights |
info:eu-repo/semantics/closedAccess |
|
dc.subject |
LANGMUIR-BLODGETT-FILMS |
|
dc.subject |
PHOTODYNAMIC THERAPY |
|
dc.subject |
IRON PHTHALOCYANINE |
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dc.subject |
METAL-FREE |
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dc.subject |
DERIVATIVES |
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dc.subject |
ZINC |
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dc.subject |
PHOTOSENSITIZERS |
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dc.subject |
SUBSTITUENTS |
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dc.subject |
AGENTS |
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dc.title |
Synthesis, in vitro inhibition effect of novel phthalocyanine complexes as carbonic anhydrase and paraoxonase enzyme inhibitors |
|
dc.type |
Article |
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dc.contributor.authorID |
Guzel, Emre/0000-0002-1142-3936 |
|
dc.contributor.authorID |
Gencer, Nahit/0000-0001-7092-8857 |
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dc.identifier.volume |
24 |
|
dc.identifier.startpage |
1047 |
|
dc.identifier.endpage |
1053 |
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dc.relation.journal |
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES |
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dc.identifier.issue |
8 |
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dc.identifier.doi |
10.1142/S1088424620500170 |
|
dc.identifier.eissn |
1099-1409 |
|
dc.contributor.author |
Guzel, Emre |
|
dc.contributor.author |
Arslan, Baris Seckin |
|
dc.contributor.author |
Cikrikci, Kubra |
|
dc.contributor.author |
Ergun, Adem |
|
dc.contributor.author |
Gencer, Nahit |
|
dc.contributor.author |
Arslan, Oktay |
|
dc.contributor.author |
Sisman, Ilkay |
|
dc.contributor.author |
Nebioglu, Mehmet |
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dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
|