dc.date.accessioned |
2021-06-08T09:11:53Z |
|
dc.date.available |
2021-06-08T09:11:53Z |
|
dc.date.issued |
2020 |
|
dc.identifier.issn |
1095-6670 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12619/96132 |
|
dc.description |
This study was supported by the Research Fund of the Balikesir universitesi Scientific Research Projects Unit (TURKEY) (2017/166). |
|
dc.description |
Bu yayının lisans anlaşması koşulları tam metin açık erişimine izin vermemektedir. |
|
dc.description.abstract |
Human carbonic anhydrase I and II isoenzymes (hCA I and II) are important metabolic enzymes. In this study, a new series of thiazol-(2(3H)-ylideneamino)benzenesulfonamide derivatives were synthesized and also some inhibition parameters including IC50(hydratese) and inhibition constant values (K-i, esterase) were determined. All studied compounds exhibited potent inhibition against these enzymes. They inhibited carbonic anhydrases (CAs) with the IC(50)values of 113 to 395.8 nM (K-i = 77.38-319.59 nM) for hCA I and 91.9 to 516 nM (K-i = 62.79-425.89 nM) for hCA II. Among the compounds,5cwas found to be the most active one (K-i: 77.38 nM) for hCA I and5gwas found for hCA II with the value of 62.79 nM. |
|
dc.description.sponsorship |
Research Fund of the Balikesir universitesi Scientific Research Projects Unit (TURKEY) [2017/166] |
|
dc.language |
English |
|
dc.language.iso |
eng |
|
dc.publisher |
WILEY |
|
dc.relation.isversionof |
10.1002/jbt.22596 |
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dc.rights |
info:eu-repo/semantics/closedAccess |
|
dc.subject |
THERAPEUTIC APPLICATIONS |
|
dc.subject |
CROSS-REACTIVITY |
|
dc.subject |
THIAZOLE |
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dc.subject |
ANTICANCER |
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dc.subject |
MECHANISM |
|
dc.subject |
ISOZYMES |
|
dc.subject |
AFFINITY |
|
dc.subject |
BEARING |
|
dc.subject |
IX |
|
dc.title |
Synthesis of new series of thiazol-(2(3H)-ylideneamino)benzenesulfonamide derivatives as carbonic anhydrase inhibitors |
|
dc.type |
Article |
|
dc.contributor.authorID |
Gencer, Nahit/0000-0001-7092-8857 |
|
dc.identifier.volume |
34 |
|
dc.relation.journal |
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY |
|
dc.identifier.issue |
12 |
|
dc.identifier.doi |
10.1002/jbt.22596 |
|
dc.identifier.eissn |
1099-0461 |
|
dc.contributor.author |
Berber, Nurcan |
|
dc.contributor.author |
Arslan, Mustafa |
|
dc.contributor.author |
Vural, Firat |
|
dc.contributor.author |
Ergun, Adem |
|
dc.contributor.author |
Gencer, Nahit |
|
dc.contributor.author |
Arslan, Oktay |
|
dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
|
dc.identifier.pmıd |
32762006 |
|