dc.date.accessioned |
2021-06-08T09:11:44Z |
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dc.date.available |
2021-06-08T09:11:44Z |
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dc.identifier.issn |
0739-1102 |
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dc.identifier.uri |
https://hdl.handle.net/20.500.12619/96074 |
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dc.description |
This work was supported by the Research Fund of the Sakarya University (Project No: 2019-5-19-174) and Sakarya University of Applied Sciences. |
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dc.description |
Bu yayının lisans anlaşması koşulları tam metin açık erişimine izin vermemektedir. |
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dc.description.abstract |
In this study, the preparation, aggregation behavior and investigation of carbonic anhydrase and cholinesterase enzyme inhibition features of non-peripherally (4-isopropylbenzyl)oxy-substituted phthalocyanines (4-6) are reported for the first time. The chemical structures of these new phthalocyanines were elucidated by UV-Vis (ultraviolet-visible), FT-IR (Fourier transform infrared spectrometry), NMR (nuclear magnetic resonance) and MALDI-TOF (matrix-assisted laser desorption/ionization time-of-flight) mass spectrometry. The substitution of 4-isopropylbenzyl)oxy groups benefits a remarkable solubility and redshift of the phthalocyanines Q-band. Also, these complexes were tested against some enzymes such as butyrylcholinesterase enzyme, human carbonic anhydrase I and II isoforms and acetylcholinesterase enzyme. The phthalocyanine complexes showed Ki values of in the range of 478.13 +/- 57.25-887.25 +/- 101.20 mu M against hCA I, 525.16 +/- 45.87-921.14 +/- 81.25 mu M against hCA II, 68.33 +/- 9.13-201.15 +/- 35.86 mu M against AChE and 86.25 +/- 13.65-237.54 +/- 24.7 mu M against BChE. Molecular docking studies were performed to investigate the binding modes and interaction energies of the (2-6) complexes with the hCA I (PDB ID:1BMZ), hCA II (PDB ID:2ABE), AChE (PDB ID:4EY6) and BChE (PDB ID:2PM8). |
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dc.description.sponsorship |
Research Fund of the Sakarya UniversitySakarya University [2019-5-19-174]; Sakarya University of Applied Sciences |
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dc.language |
English |
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dc.language.iso |
eng |
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dc.publisher |
TAYLOR & FRANCIS INC |
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dc.relation.isversionof |
10.1080/07391102.2020.1818623 |
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dc.rights |
info:eu-repo/semantics/closedAccess |
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dc.subject |
SILICON IV PHTHALOCYANINES |
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dc.subject |
PHOTODYNAMIC INACTIVATION |
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dc.subject |
METAL-COMPLEXES |
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dc.subject |
ZINC |
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dc.subject |
ELECTROCHEMISTRY |
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dc.subject |
DERIVATIVES |
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dc.subject |
INHIBITORS |
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dc.subject |
ACID |
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dc.title |
Phthalocyanine complexes with (4-isopropylbenzyl)oxy substituents: preparation and evaluation of anti-carbonic anhydrase, anticholinesterase enzymes and molecular docking studies |
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dc.type |
Article; Early Access |
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dc.contributor.authorID |
Guzel, Emre/0000-0002-1142-3936 |
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dc.contributor.authorID |
Gulcin, ilhami/0000-0001-5993-1668 |
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dc.contributor.authorID |
Taslimi, Parham/0000-0002-3171-0633 |
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dc.relation.journal |
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS |
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dc.identifier.doi |
10.1080/07391102.2020.1818623 |
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dc.identifier.eissn |
1538-0254 |
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dc.contributor.author |
Guzel, Emre |
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dc.contributor.author |
Kocyigit, Umit M. |
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dc.contributor.author |
Taslimi, Parham |
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dc.contributor.author |
Gulcin, Ilhami |
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dc.contributor.author |
Erkan, Sultan |
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dc.contributor.author |
Nebioglu, Mehmet |
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dc.contributor.author |
Arslan, Baris S. |
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dc.contributor.author |
Sisman, Ilkay |
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dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
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dc.identifier.pmıd |
32954954 |
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