dc.date.accessioned |
2021-06-08T09:11:42Z |
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dc.date.available |
2021-06-08T09:11:42Z |
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dc.date.issued |
2020 |
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dc.identifier.issn |
0378-7346 |
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dc.identifier.uri |
https://hdl.handle.net/20.500.12619/96060 |
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dc.description |
This study was supported by Sakarya University, Scientific Projects Unit by the number of 2017-08-06-014. |
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dc.description |
Bu yayının lisans anlaşması koşulları tam metin açık erişimine izin vermemektedir. |
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dc.description.abstract |
Introduction:Postterm and late-term pregnancies still remain a serious health problem, and underlying exact mechanisms are not fully elucidated. These mechanisms are influenced by many factors.Objective:The aim of this study was to investigate the relationship between plasma oxytocin and oxytocin receptor levels and oxytocin receptor polymorphisms in term and late-term pregnant women.Methods:Sixty-eight singleton pregnant women with late-term pregnancy and 83 singleton pregnant women with term parturition were included in this study. A comparison was performed between pregnancies and neonates born at term (37 0/7 and 41 6/7 weeks' gestation). Plasma oxytocin, oxytocin receptor, estradiol, and progesterone levels were measured by using enzyme-linked immunosorbent assay kits. TaqMan (R) SNP Genotyping Assays and qPCR ProbesMaster were used to investigate the polymorphisms of rs237911, rs2228485, rs53576, and rs2254298.Results:There was not any difference in gene distributions of 4 common single-nucleotide polymorphisms of oxytocin receptor of rs237911, rs2228485, rs53576, and rs2254298 between subjects in late-term and term pregnancy groups. With rs53576 of the GG genotype, serum oxytocin levels were 21.50 +/- 10.69 (ng/L) in the late-term group and 62.71 +/- 18.01 (ng/L) in the term group (p= 0.049). Oxytocin receptor levels in the late-term and term pregnancy groups of the GG genotype were 17.92 +/- 8.15 (pg/mL) and 45.77 +/- 11.66 (pg/mL), respectively (p= 0.046).Conclusion:Our findings suggest that the rs53576 oxytocin receptor single-nucleotide polymorphism is associated with late-term pregnancy through acting by direct modulation of oxytocin and oxytocin receptor levels. |
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dc.description.sponsorship |
Sakarya UniversitySakarya University [2017-08-06-014] |
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dc.language |
English |
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dc.language.iso |
eng |
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dc.publisher |
KARGER |
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dc.relation.isversionof |
10.1159/000508074 |
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dc.rights |
info:eu-repo/semantics/closedAccess |
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dc.subject |
POSTTERM DELIVERY |
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dc.subject |
PARTURITION |
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dc.subject |
RISK |
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dc.subject |
OUTCOMES |
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dc.title |
Polymorphism of the Oxytocin Receptor (OXTR) Gene Affects the Circulating Oxytocin Receptor Levels in Late-Term Pregnancy in a Turkish Population |
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dc.type |
Article |
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dc.contributor.authorID |
ozden, selcuk/0000-0002-3346-7227 |
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dc.contributor.authorID |
Akdemir, Nermin/0000-0002-9129-2103 |
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dc.identifier.volume |
85 |
|
dc.identifier.startpage |
343 |
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dc.identifier.endpage |
351 |
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dc.relation.journal |
GYNECOLOGIC AND OBSTETRIC INVESTIGATION |
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dc.identifier.issue |
4 |
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dc.identifier.doi |
10.1159/000508074 |
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dc.identifier.eissn |
1423-002X |
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dc.contributor.author |
Akdemir, Nermin |
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dc.contributor.author |
Cinemre, Fatma Behice |
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dc.contributor.author |
Cinemre, Hakan |
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dc.contributor.author |
Sevinc, Leyla |
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dc.contributor.author |
Aydemir, Birsen |
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dc.contributor.author |
Coban, Betul |
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dc.contributor.author |
Cevrioglu, Arif Serhan |
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dc.contributor.author |
Ozden, Selcuk |
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dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
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dc.identifier.pmıd |
32535602 |
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