dc.date.accessioned |
2021-06-08T09:11:34Z |
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dc.date.available |
2021-06-08T09:11:34Z |
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dc.identifier.issn |
1024-2422 |
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dc.identifier.uri |
https://hdl.handle.net/20.500.12619/96001 |
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dc.description |
Bu yayının lisans anlaşması koşulları tam metin açık erişimine izin vermemektedir. |
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dc.description.abstract |
In this work, biotransformations of dehydroepiandrosterone (DHEA) 1 by Ulocladium chartarum MRC 72584, Cladosporium sphaerospermum MRC 70266 and Cladosporium cladosporioides MRC 70282 have been reported. U. chartarum MRC 72584 mainly hydroxylated 1 at C-7 alpha and C-7 beta, accompanied by a minor hydroxylation at C-4 beta, a minor epoxidation from the beta-face and a minor oxidation at C-7 subsequent to its hydroxylations. 3 beta,7 beta-Dihydroxy-5 beta,6 beta-epoxyandrostan-17-one 6, 3 beta,4 beta,7 alpha-trihydroxyandrost-5-en-17-one 7 and 3 beta,4 beta,7 beta-trihydroxyandrost-5-en-17-one 8 from this incubation were identified as new metabolites. C. sphaerospermum MRC 70266 converted some of 1 into a 3-keto-4-ene steroid and then hydroxylated at C-6 alpha, C-6 beta and C-7 alpha, accompanied a minor 5 alpha-reduction and a minor oxidation at C-6 following its hydroxylations. C. sphaerospermum MRC 70266 also hydroxylated some of 1 at C-7 alpha and C-7 beta. C. cladosporioides MRC 70282 converted almost half of 1 into a 3-keto-4-ene steroid and then hydroxylated at C-6 alpha and C-6 beta. C. cladosporioides MRC 70282 also reduced some of 1 at C-17. |
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dc.language |
English |
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dc.language.iso |
eng |
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dc.publisher |
TAYLOR & FRANCIS LTD |
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dc.relation.isversionof |
10.1080/10242422.2020.1844191 |
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dc.rights |
info:eu-repo/semantics/closedAccess |
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dc.subject |
BIOTRANSFORMATION |
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dc.subject |
HYDROXYLATION |
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dc.subject |
STEROIDS |
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dc.title |
Microbial transformation of dehydroepiandrosterone (DHEA) by some fungi |
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dc.type |
Article; Early Access |
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dc.contributor.authorID |
YILDIRIM, Kudret/0000-0002-7889-5903 |
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dc.relation.journal |
BIOCATALYSIS AND BIOTRANSFORMATION |
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dc.identifier.doi |
10.1080/10242422.2020.1844191 |
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dc.identifier.eissn |
1029-2446 |
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dc.contributor.author |
Yildirim, Kudret |
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dc.contributor.author |
Kuru, Ali |
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dc.contributor.author |
Yilmazer Keskin, Semra |
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dc.contributor.author |
Ergin, Sinan |
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dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
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