dc.date.accessioned |
2021-06-08T09:11:18Z |
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dc.date.available |
2021-06-08T09:11:18Z |
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dc.identifier.issn |
1381-3455 |
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dc.identifier.uri |
https://hdl.handle.net/20.500.12619/95842 |
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dc.description |
Bu yayının lisans anlaşması koşulları tam metin açık erişimine izin vermemektedir. |
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dc.description.abstract |
Objectives: This study investigated the effect of dexmedetomidine on the oxidant-antioxidant (thiol/disulphide) balance. Methods: A total of 24 rats were divided into four groups. The renal arteries in groups IR (ischaemia/reperfusion) and IR + D (ischaemia/reperfusion + dexmedetomidine) were clamped for 45 min and reperfused for 180 min. Groups D (Dexmedetomidine) and IR + D were administered 100 mu g/kg dexmedetomidine. Oxidant-antioxidant (thiol/disulphide) levels were measured. Kidney tissue was examined histopathologically. Results: No statistically difference was found between the groups in terms of thiol-disulphide averages, while IMA, TOS and thiol-disulphide results showed a minimal decrease in Group IR + D compared to Group IR (p > 0.05). Tubular lesions and necrosis were found in 26-50% of tubules in Group IR. Tubular damage and necrosis in Group IR + D declined to 5-25% . Conclusions: No statistically difference was found in the study where OSI index, thiol/disulphide balance and IMA were measured together as biochemical values. |
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dc.language |
English |
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dc.language.iso |
eng |
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dc.publisher |
TAYLOR & FRANCIS LTD |
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dc.relation.isversionof |
10.1080/13813455.2020.1754431 |
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dc.rights |
info:eu-repo/semantics/closedAccess |
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dc.subject |
MYOCARDIAL-ISCHEMIA |
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dc.subject |
KIDNEY |
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dc.subject |
PATHOPHYSIOLOGY |
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dc.subject |
INFUSION |
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dc.subject |
LYCOPENE |
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dc.subject |
TISSUE |
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dc.subject |
ASSAY |
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dc.title |
Effects of dexmedetomidine on new oxidative stress markers on renal ischaemia-reperfusion injury in rats: thiol/disulphide homeostasis and the ischaemia-modified albumin |
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dc.type |
Article; Early Access |
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dc.relation.journal |
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY |
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dc.identifier.doi |
10.1080/13813455.2020.1754431 |
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dc.identifier.eissn |
1744-4160 |
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dc.contributor.author |
Acar, Muberra |
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dc.contributor.author |
Kaplan, Havva Sayhan |
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dc.contributor.author |
Erdem, Ali F. |
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dc.contributor.author |
Tomak, Yakup |
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dc.contributor.author |
Turan, Gupse |
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dc.contributor.author |
Ozdin, Mehmet |
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dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
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dc.identifier.pmıd |
32401057 |
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