Serum kallistatin level is decreased in women with preeclampsia

Abstract

Objectives: To evaluate the serum levels of the senile proteinase inhibitor kallistatin in women with preeclampsia (PE). Methods: The clinical and laboratory parameters of 55 consecutive women with early-onset PE (EOPE) and 55 consecutive women with late-onset PE (LOPE) were compared with 110 consecutive gestational age (GA)-matched (+/- 1 week) pregnant women with an uncomplicated pregnancy and an appropriate for gestational age fetus. Results: Mean serum kallistatin was significantly lower in women with PE compared to the GA-matched-controls (27.74 +/- 8.29 ng/mL vs. 37.86 +/- 20.64 ng/mL, p<0.001); in women with EOPE compared to that of women in the control group GA-matched for EOPE (24.85 +/- 6.65 ng/mL vs. 33.37 +/- 17.46 ng/mL, p=0.002); and in women with LOPE compared to that of women in the control group GA-matched for LOPE (30 .87 +/- 8.81 ng/mL vs. 42.25 +/- 22.67 ng/mL, p=0.002). Mean serum kallistatin was significantly lower in women with EOPE compared to LOPE (24.85 +/- 6.65 ng/mL vs. 30.87 +/- 8.81 ng/mL, p<0.001). Serum kallistatin had negative correlations with systolic and diastolic blood pressure, creatinine, and positive correlation with GA at sampling and GA at birth. Conclusions: Serum kallistatin levels are decreased in preeclamptic pregnancies compared to the GA-matched-controls. This decrease was also significant in women with EOPE compared to LOPE. Serum kallistatin had negative correlation with systolic and diastolic blood pressure, creatinine and positive correlation with GA at sampling and GA at birth.