dc.date.accessioned |
2021-06-03T11:02:29Z |
|
dc.date.available |
2021-06-03T11:02:29Z |
|
dc.date.issued |
2021 |
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dc.identifier.issn |
1301-5680 |
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dc.identifier.uri |
https://www.doi.org/10.5606/tgkdc.dergisi.2021.19884 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12619/95516 |
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dc.description |
Bu yayın 06.11.1981 tarihli ve 17506 sayılı Resmî Gazete’de yayımlanan 2547 sayılı Yükseköğretim Kanunu’nun 4/c, 12/c, 42/c ve 42/d maddelerine dayalı 12/12/2019 tarih, 543 sayılı ve 05 numaralı Üniversite Senato Kararı ile hazırlanan Sakarya Üniversitesi Açık Bilim ve Açık Akademik Arşiv Yönergesi gereğince açık akademik arşiv sistemine açık erişim olarak yüklenmiştir. |
|
dc.description |
Bu yayın 06.11.1981 tarihli ve 17506 sayılı Resmî Gazete’de yayımlanan 2547 sayılı Yükseköğretim Kanunu’nun 4/c, 12/c, 42/c ve 42/d maddelerine dayalı 12/12/2019 tarih, 543 sayılı ve 05 numaralı Üniversite Senato Kararı ile hazırlanan Sakarya Üniversitesi Açık Bilim ve Açık Akademik Arşiv Yönergesi gereğince açık akademik arşiv sistemine açık erişim olarak yüklenmiştir. |
|
dc.description.abstract |
Background: This study aims to evaluate the effect of amantadine on lung tissue of after lower limb ischemia/reperfusion injury in rats. Methods: A total of 24 Wistar rats were divided into four equal groups including six rats in each: sham group (Group S), amantadine group (Group A), ischemia/reperfusion group (Group I/R), and ischemia/reperfusion + amantadine group (Group I/R-A). All groups underwent a midline abdominal incision. In Groups I/R and I/R-A, the infrarenal abdominal aorta was clamped for 120 min and, then, reperfused for 120 min after removal of the clamp. Amantadine hydrochloride 45 mg/kg was administered intraperitoneally to the rats of Groups A and Group I/R-A 15 min before surgery. At the end of reperfusion period (240 min), all rats were sacrificed, and their lung tissues were obtained. Lung tissue catalase and superoxide dismutase activities and glutathione S-transferase and malondialdehyde levels were analyzed. Lung tissues were examined histopathologically. Results: Catalase activity was lower in Groups A, I/R, and I/R-A compared to Group S. Superoxide dismutase activity was higher in Group I/R than Group S. Superoxide dismutase activity in Groups I/R-A and A decreased, compared to Groups S and I/R. Glutathione S-transferase levels decreased in Groups I/R and A, compared to Group S. Glutathione S-transferase levels in Group I/R-A were higher than Groups I/R and A. The highest level of malondialdehyde was found in Group I/R and the lowest level was found in Group I/R-A. According to histopathological examination, infiltration scores were significantly lower in Group S than Groups I/R and I/R-A (p=0.009 and p=0.011, respectively). The alveolar wall thickening scores in Group I/R were also significantly higher than Groups S and Group A (p=0.001 and p=0.001, respectively). Conclusion: Lung tissue can be affected histopathologically by ischemia/ reperfusion injury and this injury can be reversed by amantadine administration. |
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dc.language |
English |
|
dc.language.iso |
eng |
|
dc.publisher |
BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK |
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dc.relation.isversionof |
10.5606/tgkdc.dergisi.2021.19884 |
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dc.rights |
info:eu-repo/semantics/openAccess |
|
dc.subject |
Amantadine |
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dc.subject |
ischemia/reperfusion |
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dc.subject |
lower limb |
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dc.subject |
lung |
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dc.title |
The effects of amantadine on lung tissue in lower limb ischemia/reperfusion injury model in rats |
|
dc.type |
Article |
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dc.identifier.volume |
29 |
|
dc.identifier.startpage |
78 |
|
dc.identifier.endpage |
84 |
|
dc.relation.journal |
TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY |
|
dc.identifier.issue |
1 |
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dc.identifier.wos |
WOS:000612350500011 |
|
dc.identifier.doi |
10.5606/tgkdc.dergisi.2021.19884 |
|
dc.contributor.author |
Orhan, Mustafa |
|
dc.contributor.author |
Tuna, Ayca Tas |
|
dc.contributor.author |
Unal, Yusuf |
|
dc.contributor.author |
Arslan, Mustafa |
|
dc.contributor.author |
Yazar, Hayrullah |
|
dc.contributor.author |
Sezen, Saban Cem |
|
dc.contributor.author |
Gozukara, Sezen Irmak |
|
dc.contributor.author |
Palabiyik, Onur |
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dc.relation.publicationcategory |
Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı |
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dc.identifier.pmıd |
33768984 |
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dc.rights.openaccessdesignations |
Green Published, Bronze |
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