Transforming Growth Factor-beta 1 Induced Urethral Fibrosis in a Rat Model

Premsant Sangkum; Gökçe, Ahmet; Ronny B. W. Tan; Mostafa Bouljihad; Hogyoung Kim; Sree Harsha Mandava; Sarmad N. Saleem; George F. Lasker; Faysal A. Yafi; Zakaria Y. Abd Elmageed; Krishnarao Moparty; Suresh C. Sikka; Asim B. Abdel-Mageed; Wayne J. G. Hellstrom

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Transforming Growth Factor-beta 1 Induced Urethral Fibrosis in a Rat Model

Premsant Sangkum; Gökçe, Ahmet; Ronny B. W. Tan; Mostafa Bouljihad; Hogyoung Kim; Sree Harsha Mandava; Sarmad N. Saleem; George F. Lasker; Faysal A. Yafi; Zakaria Y. Abd Elmageed; Krishnarao Moparty; Suresh C. Sikka; Asim B. Abdel-Mageed; Wayne J. G. Hellstrom

URI: https://hdl.handle.net/20.500.12619/6978
https://doi.org/10.1016/j.juro.2015.02.014

Date: 2015

Abstract:

Conclusions: TGF-beta 1 injection can successfully generate a reproducible rat model of urethral spongiofibrosis. This technique is simple, inexpensive and reproducible. Our series is a proof of concept study. Additional studies in larger animals are needed to further confirm our findings.

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