Diagnosis of Vitamin B-12 Deficiency in Patients With Myeloproliferative Disorders

Abstract

Conclusions: Patients who had myeloproliferative disorders had a high prevalence of vitamin B-12 deficiency, despite high serum vitamin B-12 levels. Therefore, vitamin B-12 status should be evaluated in patients with myeloproliferative disorders. Holotranscobalamin level may be the best initial test and may replace vitamin B-12 assay to accompany MMA and homocysteine levels.