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Results of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitis

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dc.contributor.authors Erdem, H; Cag, Y; Ozturk-Engin, D; Defres, S; Kaya, S; Larsen, L; Poljak, M; Barsic, B; Argemi, X; Sorensen, SM; Bohr, AL; Tattevin, P; Gunst, JD; Bastakova, L; Jereb, M; Johansen, IS; Karabay, O; Pekok, AU; Sipahi, OR; Chehri, M; Beraud, G; Shehata, G; Del Vecchio, RF; Maresca, M; Karsen, H; Sengoz, G; Sunbul, M; Yilmaz, G; Yilmaz, H; Sharif-Yakan, A; Kanj, SS; Parlak, E; Pehlivanoglu, F; Korkmaz, F; Komur, S; Kose, S; Ulug, M; Bolukcu, S; Coskuner, SA; Ince, N; Akkoyunlu, Y; Halac, G; Sahin-Horasan, E; Tireli, H; Kilicoglu, G; Al-Mandawi, A; Nemli, SA; Inan, A; Senbayrak, S; Stahl, JP; Vahaboglu, H;
dc.date.accessioned 2020-02-27T08:43:08Z
dc.date.available 2020-02-27T08:43:08Z
dc.date.issued 2015
dc.identifier.citation Erdem, H; Cag, Y; Ozturk-Engin, D; Defres, S; Kaya, S; Larsen, L; Poljak, M; Barsic, B; Argemi, X; Sorensen, SM; Bohr, AL; Tattevin, P; Gunst, JD; Bastakova, L; Jereb, M; Johansen, IS; Karabay, O; Pekok, AU; Sipahi, OR; Chehri, M; Beraud, G; Shehata, G; Del Vecchio, RF; Maresca, M; Karsen, H; Sengoz, G; Sunbul, M; Yilmaz, G; Yilmaz, H; Sharif-Yakan, A; Kanj, SS; Parlak, E; Pehlivanoglu, F; Korkmaz, F; Komur, S; Kose, S; Ulug, M; Bolukcu, S; Coskuner, SA; Ince, N; Akkoyunlu, Y; Halac, G; Sahin-Horasan, E; Tireli, H; Kilicoglu, G; Al-Mandawi, A; Nemli, SA; Inan, A; Senbayrak, S; Stahl, JP; Vahaboglu, H; (2015). Results of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitis. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 59, 3089-3084
dc.identifier.issn 0066-4804
dc.identifier.uri https://doi.org/10.1128/AAC.05016-14
dc.identifier.uri https://hdl.handle.net/20.500.12619/66781
dc.description.abstract Data in the literature regarding the factors that predict unfavorable outcomes in adult herpetic meningoencephalitis (HME) cases are scarce. We conducted a multicenter study in order to provide insights into the predictors of HME outcomes, with special emphasis on the use and timing of antiviral treatment. Samples from 501 patients with molecular confirmation from cerebrospinal fluid were included from 35 referral centers in 10 countries. Four hundred thirty-eight patients were found to be eligible for the analysis. Overall, 232 (52.9%) patients experienced unfavorable outcomes, 44 died, and 188 survived, with sequelae. Age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02 to 1.05), Glasgow Coma Scale score (OR, 0.84; 95% CI, 0.77 to 0.93), and symptomatic periods of 2 to 7 days (OR, 1.80; 95% CI, 1.16 to 2.79) and >7 days (OR, 3.75; 95% CI, 1.72 to 8.15) until the commencement of treatment predicted unfavorable outcomes. The outcome in HME patients is related to a combination of therapeutic and host factors. This study suggests that rapid diagnosis and early administration of antiviral treatment in HME patients are keys to a favorable outcome.
dc.language English
dc.publisher AMER SOC MICROBIOLOGY
dc.subject Pharmacology & Pharmacy
dc.title Results of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitis
dc.type Article
dc.identifier.volume 59
dc.identifier.startpage 3084
dc.identifier.endpage 3089
dc.contributor.department Sakarya Üniversitesi/İlahiyat Fakültesi/Temel İslam Bilimleri Bölümü
dc.contributor.saüauthor Kaya, Süleyman
dc.contributor.saüauthor Karabay, Oğuz
dc.relation.journal ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
dc.identifier.wos WOS:000358623200015
dc.identifier.doi 10.1128/AAC.05016-14
dc.identifier.eissn 1098-6596
dc.contributor.author Hakan Erdem
dc.contributor.author Yasemin Cag
dc.contributor.author Derya Ozturk-Engin
dc.contributor.author Sylviane Defres
dc.contributor.author Kaya, Süleyman
dc.contributor.author Lykke Larsen
dc.contributor.author Mario Poljak
dc.contributor.author Bruno Barsic
dc.contributor.author Xavier Argemi
dc.contributor.author Signe Maj Sorensen
dc.contributor.author Anne Lisbeth Bohr
dc.contributor.author Pierre Tattevin
dc.contributor.author Jesper Damsgaard Gunst
dc.contributor.author Lenka Bastakova
dc.contributor.author Matjaz Jereb
dc.contributor.author Isik Somuncu Johansen
dc.contributor.author Karabay, Oğuz
dc.contributor.author Abdullah Umut Pekok
dc.contributor.author Oguz Resat Sipahi
dc.contributor.author Mahtab Chehri
dc.contributor.author Guillaume Beraud
dc.contributor.author Ghaydaa Shehata
dc.contributor.author Rosa Fontana Del Vecchio


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