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Phototherapy causes a transient DNA damage in jaundiced newborns

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dc.contributor.authors Kahveci, H; Dogan, H; Karaman, A; Caner, I; Tastekin, A; Ikbal, M;
dc.date.accessioned 2020-02-27T08:38:33Z
dc.date.available 2020-02-27T08:38:33Z
dc.date.issued 2013
dc.identifier.citation Kahveci, H; Dogan, H; Karaman, A; Caner, I; Tastekin, A; Ikbal, M; (2013). Phototherapy causes a transient DNA damage in jaundiced newborns. DRUG AND CHEMICAL TOXICOLOGY, 36, 92-88
dc.identifier.issn 0148-0545
dc.identifier.uri https://doi.org/10.3109/01480545.2011.653491
dc.identifier.uri https://hdl.handle.net/20.500.12619/66619
dc.description.abstract In this study, we aimed to clarify the following questions: 1) Does phototherapy (PT) cause genotoxicity in full-term newborn babies undergoing PT as a result of neonatal jaundice?, 2) if genotoxic effect occurs, is there any relationship between the duration of PT and genotoxicity?, and 3) is genotoxic effect temporary or not? The frequency of sister chromatid exchange (SCE) was determined in jaundiced newborns before, during, and after phototherapy, then determined again in childhood (approximately 3.5 years old). Mean frequency of SCE of 22 full-term jaundiced babies significantly increased during the PT procedure and in every single day, compared to the previous day, in comparison to the pre-PT basal value (6.20 +/- 0.57;); mean SCE frequencies at 24, 48, 72, and 96 hours were 7.75 +/- 0.40, 8.16 +/- 0.47, 8.50 +/- 0.40, and 9.36 +/- 0.55, respectively (all P-values < 0.01). In childhood, no significant difference was found between the mean SCE value (4.9 +/- 0.9) of 20 of 22 children, who received PT in the neonatal period, and the mean SCE value (4.7 +/- 0.6) of 20 coevaluated healthy children (P = 0.40). This study demonstrates that the negative effect of PT on SCE is a temporary effect.
dc.language English
dc.subject Toxicology
dc.title Phototherapy causes a transient DNA damage in jaundiced newborns
dc.type Article
dc.identifier.volume 36
dc.identifier.startpage 88
dc.identifier.endpage 92
dc.contributor.department Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü
dc.contributor.saüauthor Caner, İbrahim
dc.identifier.wos WOS:000311836600011
dc.identifier.doi 10.3109/01480545.2011.653491
dc.contributor.author Hasan Kahveci
dc.contributor.author Hasan Dogan
dc.contributor.author Ali Karaman
dc.contributor.author Caner, İbrahim
dc.contributor.author Ayhan Tastekin
dc.contributor.author Mevlit Ikbal

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