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The relationship between oxytocin, vasopressin and atrial natriuretic peptide levels and cognitive functions in patients with schizophrenia

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dc.contributor.authors Pek, TM; Yazici, E; Guzel, D; Kose, E; Yazici, AB; Erol, A;
dc.date.accessioned 2020-02-27T08:28:23Z
dc.date.available 2020-02-27T08:28:23Z
dc.date.issued 2019
dc.identifier.citation Pek, TM; Yazici, E; Guzel, D; Kose, E; Yazici, AB; Erol, A; (2019). The relationship between oxytocin, vasopressin and atrial natriuretic peptide levels and cognitive functions in patients with schizophrenia. PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, , -
dc.identifier.issn 2475-0573
dc.identifier.uri https://doi.org/10.1080/24750573.2019.1653149
dc.identifier.uri https://hdl.handle.net/20.500.12619/66058
dc.description.abstract Objective: The aim of this study was to investigate the relationship between oxytocin (OXT), vasopressin (AVP) and atrial natriuretic peptide (ANP) levels and cognitive functions in schzophrenia as well as to compare the findings to those in healthy controls. Method: Patients with chronic schizophrenia and (n=63) healthy controls (n=60) were evaluated with the Rey Auditory Verbal Learning Test (VLT), the Trail Making Test A-B (TMT), the Stroop Test, the Wechsler Memory Scale-Visual Production Subscale (WMS-V) and the Facial Emotion Recognition Tests. Blood samples were analysed by using ELISA. In the data analysis, the percentage distributions of the variables were obtained, the centrality and prevalence measures (mean, standard deviation) were calculated for the continuous variables, and the dependent and independent variables were evaluated using the chi-square test, the Student's t-test, and the Pearson correlation test. High score variables were determined by principal component analysis. For comparisons between groups; MANOVA applied. Results: Serum OXT, AVP and ANP levels did not differ between the groups. In the healthy control group, subscales of the Stroop, WMS-V and TMT-B tests showed better scores and correlated with levels of OXT (p < .05). In the healthy controls, ANP levels and social cognition had a relationship with response times to happy facial expressions (p < .05). The correlations of OXT, AVP and ANP with the social and cognitive parameters were different between the control group and the schizophrenia group (p < .05). Conclusion: The different correlations in the healthy controls and schizophrenia group suggest deteriorations in the interactions and functions of hormones in patients and highlights the need for new investigations into different neurodegenerative illness samples.
dc.language English
dc.publisher TAYLOR & FRANCIS LTD
dc.subject Psychiatry
dc.title The relationship between oxytocin, vasopressin and atrial natriuretic peptide levels and cognitive functions in patients with schizophrenia
dc.type Early Access
dc.contributor.department Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü
dc.contributor.saüauthor Yazıcı, Esra
dc.contributor.saüauthor Güzel, Derya
dc.contributor.saüauthor Köse, Elif
dc.contributor.saüauthor Yazıcı, Ahmet Bülent
dc.contributor.saüauthor Erol, Atila
dc.relation.journal PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
dc.identifier.wos WOS:000481553100001
dc.identifier.doi 10.1080/24750573.2019.1653149
dc.identifier.eissn 2475-0581
dc.contributor.author Tugba Mutu Pek
dc.contributor.author Yazıcı, Esra
dc.contributor.author Güzel, Derya
dc.contributor.author Köse, Elif
dc.contributor.author Yazıcı, Ahmet Bülent
dc.contributor.author Erol, Atila


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