A Case of Hepatitis B Reactivation with Acute Flare Three Months After Tenofovir Prophylaxis Withdrawal in a Allogenic Hematopoietic Stem Cell Transplantation Patient

Abstract

Hepatitis B virus (HBV) infection is a major health problem worldwide. HBV reactivation is associated with high mortality rates in hematopoietic stem cell transplantation (HSCT) and, prophylactic antiviral treatment is suggested to prevent this phenomenon. However, the duration of antiviral treatment in HSCT patients is not fully defined and the time of immune recovery is considered the best parameter for a drug to be safely interrupted. We aimed to present a case of hepatitis B reactivation after cessation of one-year prophylactic tenofovir treatment in a anti-hepatitis B core immunoglobulin G-positive patient who received allogenic HSCT treatment for chronic lymphocytic leukemia.