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Roles of selenoprotein K and selenium status in the etiopathogenesis of preeclampsia: Their relationships with maternal lipid peroxidation, oxidative DNA damage, and glutathione peroxidase

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dc.contributor.authors Cinemre, FBS; Aydemir, B; Gulyasar, T; Cinemre, H; Tuten, A; Yolmaz, N; Yoldoz, M; Bahtiyar, N; Kozoler, AR; Abalo, R;
dc.date.accessioned 2020-02-27T08:27:06Z
dc.date.available 2020-02-27T08:27:06Z
dc.date.issued 2018
dc.identifier.citation Cinemre, FBS; Aydemir, B; Gulyasar, T; Cinemre, H; Tuten, A; Yolmaz, N; Yoldoz, M; Bahtiyar, N; Kozoler, AR; Abalo, R; (2018). Roles of selenoprotein K and selenium status in the etiopathogenesis of preeclampsia: Their relationships with maternal lipid peroxidation, oxidative DNA damage, and glutathione peroxidase. TRACE ELEMENTS AND ELECTROLYTES, 35, 130-124
dc.identifier.issn 0946-2104
dc.identifier.uri https://doi.org/10.5414/TEX01512
dc.identifier.uri https://hdl.handle.net/20.500.12619/65920
dc.description.abstract Objective: Preeclampsia (PE) is a complex disease and the underlying mechanisms are not known yet. It is well known that selenium and oxidative stress play a role in the pathogenesis of various diseases as well as PE. The aim of the study was to investigate the changes in selenium status, as an essential trace element, and selenoprotein K (SelK), a newly described selenoprotein which has been suggested to have an antioxidant function in some tissues in patients with preeclampsia. We also aimed at investigating their relationships with maternal lipid peroxidation, oxidative DNA damage, and glutathione peroxidase (GPx) activities. Materials and methods: 38 healthy pregnant and 48 pregnant women with PE were included in the study. Serum selenium levels were measured by graphite-furnace atomic absorption spectrophotometry. Plasma TBARS levels were analyzed by spectrophotometric method; GPx activities, 8OHdG, and SelK levels were determined by ELISA. Results: Plasma TBARS and 8OHdG levels were found to be increased in the PE group compared to the healthy pregnant group. Plasma SelK levels and GPx activities were found to be lower in the PE group than in the healthy control group. However, there was no significant difference in serum selenium levels between two groups. Furthermore, a significant correlation was determined between plasma SelK levels and GPx activities in PE patients group (r = 0.743; p < 0.01). Likewise, a significant positive correlation was found between plasma 8OHdG and TBARS levels (r = 0.457; p < 0.01), serum selenium levels and plasma GPx activities (r = 0.663; p < 0.01), serum selenium and plasma SelK levels (r = 0.851; p < 0.01) in PE. Conclusion: Our findings indicated that a selenoprotein SelK and a selenoenzyme GPx play a role in the etiopathogenesis of PE. Decreases in these antioxidant systems were associated with increase in lipid and DNA oxidation in PE patients. Underlying mechanisms of SelK and its interactions with selenium status and GPx in PE should be clarified in details with further studies.
dc.language English
dc.publisher DUSTRI-VERLAG DR KARL FEISTLE
dc.subject Endocrinology & Metabolism
dc.title Roles of selenoprotein K and selenium status in the etiopathogenesis of preeclampsia: Their relationships with maternal lipid peroxidation, oxidative DNA damage, and glutathione peroxidase
dc.type Article
dc.identifier.volume 35
dc.identifier.startpage 124
dc.identifier.endpage 130
dc.contributor.department Sakarya Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü
dc.contributor.saüauthor Cinemre, Fatma Behice
dc.contributor.saüauthor Aydemir, Birsen
dc.contributor.saüauthor Cinemre, Hakan
dc.relation.journal TRACE ELEMENTS AND ELECTROLYTES
dc.identifier.wos WOS:000435533800004
dc.identifier.doi 10.5414/TEX01512
dc.contributor.author Cinemre, Fatma Behice
dc.contributor.author Aydemir, Birsen
dc.contributor.author Tevfik Gulyasar
dc.contributor.author Cinemre, Hakan
dc.contributor.author Abdullah Tuten
dc.contributor.author Nevin Yolmaz
dc.contributor.author Mustafa Yoldoz
dc.contributor.author Nurten Bahtiyar
dc.contributor.author Ali Roza Kozoler
dc.contributor.author Remzi Abalo


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