Is Change in Hemoglobin Level a Predictive Biomarker of Tyrosine Kinase Efficacy in Metastatic Renal Cell Carcinoma? A Turkish Oncology Group Study

Bilir, Cemil; Ibrahim Yildiz; Ahmet Bilici; Mahmut Ucar; Veli Berk; Yasar Yildiz; Ozan Yazici; Goksen Inanc Imamoglu; Nuri Karadurmus; Kezban Nur Pilanci; Erkan Arpaci; Ozgur Tanriverdi; Ebru Karci; Suleyman Temiz; Erdinc Nayir; Esin Oktay; Pinar Dal; Ibrahim Petekkaya; Varım, Ceyhun; Cinemre, Hakan

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dc.contributor.authors	Bilir, C; Yildiz, I; Bilici, A; Ucar, M; Berk, V; Yildiz, Y; Yazici, O; Imamoglu, GI; Karadurmus, N; Pilanci, KN; Arpaci, E; Tanriverdi, O; Karci, E; Temiz, S; Nayir, E; Oktay, E; Dal, P; Petekkaya, I; Varim, C; Cinemre, H;
dc.date.accessioned	2020-02-27T08:26:51Z
dc.date.available	2020-02-27T08:26:51Z
dc.date.issued	2017
dc.identifier.citation	Bilir, C; Yildiz, I; Bilici, A; Ucar, M; Berk, V; Yildiz, Y; Yazici, O; Imamoglu, GI; Karadurmus, N; Pilanci, KN; Arpaci, E; Tanriverdi, O; Karci, E; Temiz, S; Nayir, E; Oktay, E; Dal, P; Petekkaya, I; Varim, C; Cinemre, H; (2017). Is Change in Hemoglobin Level a Predictive Biomarker of Tyrosine Kinase Efficacy in Metastatic Renal Cell Carcinoma? A Turkish Oncology Group Study. CANCER INVESTIGATION, 35, 255-248
dc.identifier.issn	0735-7907
dc.identifier.uri	https://doi.org/10.1080/07357907.2017.1292518
dc.identifier.uri	https://hdl.handle.net/20.500.12619/65884
dc.description.abstract	Background: There are insufficient predictive markers for renal cell carcinoma (RCC). Methods: A total of 308 metastatic RCC patients were analyzed retrospectively. Results: The increased hemoglobin (Hb) group had significantly higher progression-free survival and overall survival (OS) compared with the decreased Hb group at 11.5 versus 6.35months (p < .001) and 21.0 versus 11.36months (p < .001) respectively. The 1- and 3-year OS rates were higher in the Hb increased group, i.e., 84% versus 64% and 52% versus 35% respectively. Conclusions: The present study showed that increased Hb levels after tyrosine kinase inhibitor therapy could be a predictive marker of RCC.
dc.language	English
dc.publisher	TAYLOR & FRANCIS INC
dc.subject	Oncology
dc.title	Is Change in Hemoglobin Level a Predictive Biomarker of Tyrosine Kinase Efficacy in Metastatic Renal Cell Carcinoma? A Turkish Oncology Group Study
dc.type	Article
dc.identifier.volume	35
dc.identifier.startpage	248
dc.identifier.endpage	255
dc.contributor.department	Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü
dc.contributor.saüauthor	Bilir, Cemil
dc.contributor.saüauthor	Varım, Ceyhun
dc.contributor.saüauthor	Cinemre, Hakan
dc.relation.journal	CANCER INVESTIGATION
dc.identifier.wos	WOS:000399505100004
dc.identifier.doi	10.1080/07357907.2017.1292518
dc.identifier.eissn	1532-4192
dc.contributor.author	Bilir, Cemil
dc.contributor.author	Ibrahim Yildiz
dc.contributor.author	Ahmet Bilici
dc.contributor.author	Mahmut Ucar
dc.contributor.author	Veli Berk
dc.contributor.author	Yasar Yildiz
dc.contributor.author	Ozan Yazici
dc.contributor.author	Goksen Inanc Imamoglu
dc.contributor.author	Nuri Karadurmus
dc.contributor.author	Kezban Nur Pilanci
dc.contributor.author	Erkan Arpaci
dc.contributor.author	Ozgur Tanriverdi
dc.contributor.author	Ebru Karci
dc.contributor.author	Suleyman Temiz
dc.contributor.author	Erdinc Nayir
dc.contributor.author	Esin Oktay
dc.contributor.author	Pinar Dal
dc.contributor.author	Ibrahim Petekkaya
dc.contributor.author	Varım, Ceyhun
dc.contributor.author	Cinemre, Hakan