Browsing Makale Koleksiyonu by Author "Sarisozen, C; Tan, Y; Liu, J; Bilir, C; Shen, L; Filipczak, N; Porter, TM; Torchilin, VP;"

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MDM2 antagonist-loaded targeted micelles in combination with doxorubicin: effective synergism against human glioblastoma via p53 re-activation

C. Sarisozen; Y. Tan; J. Liu; Bilir, Cemil; L. Shen; N. Filipczak; T. M. Porter; V. P. Torchilin (TAYLOR & FRANCIS LTD, 2019)

p53, The tumour suppressor protein encoded by P53 gene, is the most commonly altered protein in the human malignancies. MDM2 controls the p53 activity through an autoregulatory feedback loop. p53 activates the expression ...