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Association of selenoprotein W1 (rs3786777) polymorphism, maternal plasma selenoprotein W (SelW), and selenium levels in patients with pre-eclampsia

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dc.contributor.authors Cinemre, FBS; Cinemre, H; Erdogan, E; Dilaveroglu, N; Tuten, A; Kaya, B; Yilmaz, N; Gulyasar, T; Yildiz, M; Bahtiyar, N; Kiziler, AR; Aydemir, B;
dc.date.accessioned 2020-02-27T07:22:31Z
dc.date.available 2020-02-27T07:22:31Z
dc.date.issued 2019
dc.identifier.citation Cinemre, FBS; Cinemre, H; Erdogan, E; Dilaveroglu, N; Tuten, A; Kaya, B; Yilmaz, N; Gulyasar, T; Yildiz, M; Bahtiyar, N; Kiziler, AR; Aydemir, B; (2019). Association of selenoprotein W1 (rs3786777) polymorphism, maternal plasma selenoprotein W (SelW), and selenium levels in patients with pre-eclampsia. TRACE ELEMENTS AND ELECTROLYTES, 36, 67-61
dc.identifier.issn 0946-2104
dc.identifier.uri https://doi.org/10.5414/TEX01542
dc.identifier.uri https://hdl.handle.net/20.500.12619/65612
dc.description.abstract Objective: To investigate the role of selenoprotein W1 (SEPW1) single nucleotide polymorphism (SNP) in etiopathogenesis of pre-eclampsia (PE) and its association with maternal selenoprotein W (SelW) and selenium levels. Materials and methods: In this study, 98 pregnant women who were diagnosed with PE and 100 healthy pregnant controls were investigated. To identify the polymorphism of the SEPW1 gene (rs3786777), allele-specific polymerase chain reaction (ASPCR) analysis was used. Serum selenium levels and plasma SelW levels were measured by graphite-furnace atomic absorption spectrophotometry and by ELISA, respectively. Results: Maternal selenium levels (mu g/L) were 92.56 +/- 6.10 and 86.26 +/- 6.33 in pregnant women with and without PE, respectively (p > 0.05). On the other hand, SelW levels (ng/mL) were significantly lower in PE (72.08 +/- 8.10) compared to controls (89.29 +/- 6.99) (p < 0.01). The frequencies of the CC, CA, and AA genotypes were found to be 26%, 61%, and 13% in pregnant women with PE and 28%, 55%, and 17% in healthy pregnant controls. The distribution of the SEPW1 genotypes and alleles did not differ significantly among subjects with and without PE. In PE patients, SelW levels were lower in CC and CA genotypes compared to controls (p < 0.05 and p < 0.001). Conclusion: SEPW1 gene polymorphism did not seem to affect risk of PE in our population. However, SelW levels were low in some genotypes of the gene, suggesting that SelW might have played a role in the etiopathogenesis of PE.
dc.language English
dc.publisher DUSTRI-VERLAG DR KARL FEISTLE
dc.subject Endocrinology & Metabolism
dc.title Association of selenoprotein W1 (rs3786777) polymorphism, maternal plasma selenoprotein W (SelW), and selenium levels in patients with pre-eclampsia
dc.type Article
dc.identifier.volume 36
dc.identifier.startpage 61
dc.identifier.endpage 67
dc.contributor.department Sakarya Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü
dc.contributor.saüauthor Cinemre, Fatma Behice
dc.contributor.saüauthor Cinemre, Hakan
dc.contributor.saüauthor Yıldız, Mustafa
dc.contributor.saüauthor Aydemir, Birsen
dc.relation.journal TRACE ELEMENTS AND ELECTROLYTES
dc.identifier.wos WOS:000461900500002
dc.identifier.doi 10.5414/TEX01542
dc.contributor.author Cinemre, Fatma Behice
dc.contributor.author Cinemre, Hakan
dc.contributor.author Elif Erdogan
dc.contributor.author Nilgun Dilaveroglu
dc.contributor.author Abdullah Tuten
dc.contributor.author Baris Kaya
dc.contributor.author Nevin Yilmaz
dc.contributor.author Tevfik Gulyasar
dc.contributor.author Yıldız, Mustafa
dc.contributor.author Nurten Bahtiyar
dc.contributor.author Ali Riza Kiziler
dc.contributor.author Aydemir, Birsen


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