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Evaluation of metallothionein-1, metallothionein-2, lipid peroxidation and trace elements status in the progression of the spontaneous mitral chordae tendineae rupture patients

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dc.contributor.authors Aydemir, B; Cinemre, FBS; Cinemre, H; Kiziler, AR; Akdemir, R; Vatan, MB; Kilic, MA; Bahtiyar, N; Akkoyun, DC;
dc.date.accessioned 2020-02-27T07:19:55Z
dc.date.available 2020-02-27T07:19:55Z
dc.date.issued 2016
dc.identifier.citation Aydemir, B; Cinemre, FBS; Cinemre, H; Kiziler, AR; Akdemir, R; Vatan, MB; Kilic, MA; Bahtiyar, N; Akkoyun, DC; (2016). Evaluation of metallothionein-1, metallothionein-2, lipid peroxidation and trace elements status in the progression of the spontaneous mitral chordae tendineae rupture patients. TRACE ELEMENTS AND ELECTROLYTES, 33, 170-162
dc.identifier.issn 0946-2104
dc.identifier.uri https://doi.org/10.5414/TEX01452
dc.identifier.uri https://hdl.handle.net/20.500.12619/65470
dc.description.abstract Objective: The aim of the present study was to investigate whether copper, zinc and iron levels and copper/zinc, iron/zinc, iron/copper ratios in serum and erythrocytes are associated with lipid oxidation levels, metallothionein-1 (MT-1), and metallothionein-2 (MT-2) levels in plasma in the context of pathogenesis of the mitral chordae tendineae rupture (MCTR). Methods: 65 subjects who were identical in demographic characteristics' were selected for the study; 33 with MCTR patients, and 32 healthy control subjects. The levels of MT-1, MT-2, and malondialdehyde as measure of lipid oxidation, and trace elements were determined by enzyme-linked immunosorbent assay, spectrophotometric method, and inductively coupled plasma optical emission spectrometry, respectively. Results: Serum zinc levels were found to be lower in the patients' group when compared to control group. The copper and iron levels in serum, MT-1, MT-2; malondialdehyde levels in plasma, iron and malondialdehyde levels in erythrocytes; serum copper/zinc and iron/zinc ratios were found to be higher in the patients' group when compared to controls. Conclusions: We conclude that the changes of oxidant antioxidant system balance and trace element status may contribute to the etiopathogenesis of MCTR.
dc.language English
dc.publisher DUSTRI-VERLAG DR KARL FEISTLE
dc.subject Endocrinology & Metabolism
dc.title Evaluation of metallothionein-1, metallothionein-2, lipid peroxidation and trace elements status in the progression of the spontaneous mitral chordae tendineae rupture patients
dc.type Article
dc.identifier.volume 33
dc.identifier.startpage 162
dc.identifier.endpage 170
dc.contributor.department Sakarya Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü
dc.contributor.saüauthor Cinemre, Fatma Behice
dc.contributor.saüauthor Cinemre, Hakan
dc.contributor.saüauthor Akdemir, Ramazan
dc.contributor.saüauthor Vatan, Mehmet Bülent
dc.relation.journal TRACE ELEMENTS AND ELECTROLYTES
dc.identifier.wos WOS:000388286600006
dc.identifier.doi 10.5414/TEX01452
dc.contributor.author Cinemre, Fatma Behice
dc.contributor.author Cinemre, Hakan
dc.contributor.author Akdemir, Ramazan
dc.contributor.author Vatan, Mehmet Bülent


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