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Comparison of the Efficacy of Methotrexate and Narrow-Band Ultraviolet B for the Treatment of Plaque-Type Psoriasis

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dc.contributor.authors Solak, B; Dikicier, BS; Yaldiz, M; Erkorkmaz, U; Erdem, T;
dc.date.accessioned 2020-02-27T07:19:33Z
dc.date.available 2020-02-27T07:19:33Z
dc.date.issued 2016
dc.identifier.citation Solak, B; Dikicier, BS; Yaldiz, M; Erkorkmaz, U; Erdem, T; (2016). Comparison of the Efficacy of Methotrexate and Narrow-Band Ultraviolet B for the Treatment of Plaque-Type Psoriasis. AMERICAN JOURNAL OF THERAPEUTICS, 23, E410-E405
dc.identifier.issn 1075-2765
dc.identifier.uri https://doi.org/10.1097/MJT.0000000000000128
dc.identifier.uri https://hdl.handle.net/20.500.12619/65445
dc.description.abstract Although many treatment methods for psoriasis are available, it is still a challenging task for the dermatologist to choose the optimal one. To the best of our knowledge, there was only 1 small study of head-to-head comparison of the efficacy of these medications to date. In this retrospective study, we compared the clinical efficacy and recurrence rates of narrow-band ultraviolet B (NB-UVB) and methotrexate (MTX) treatments for plaque-type psoriasis. Sixty-seven patients with psoriasis who received NB-UVB (n = 35) or MTX (n = 32) treatments were included in the study. Response was assessed by Psoriasis Area and Severity Index (PASI) at baseline, 4th and 12th week. Our results revealed that both treatment modalities significantly reduced the PASI score compared with baseline (P < 0.001 and P < 0.001, respectively). Moreover, there was no significant difference between both regimens regardless of baseline PASI scores (P = 0.796 at 4th week and P = 0.606 at 12th week). Recurrence rates in both treatments were also similar at 3 months (42.9% for NB-UVB and 65.2% for MTX, P = 0.162). In conclusion, the use of NB-UVB can be considered as a preliminary treatment method rather than MTX when taking into account of the lower side effect profile even in patients with severe psoriasis.
dc.language English
dc.publisher LIPPINCOTT WILLIAMS & WILKINS
dc.subject Pharmacology & Pharmacy
dc.title Comparison of the Efficacy of Methotrexate and Narrow-Band Ultraviolet B for the Treatment of Plaque-Type Psoriasis
dc.type Article
dc.identifier.volume 23
dc.identifier.startpage E405
dc.identifier.endpage E410
dc.contributor.department Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü
dc.contributor.saüauthor Solak, Berna
dc.contributor.saüauthor Sevimli Dikicier, Bahar
dc.contributor.saüauthor Yaldız, Mahizer
dc.contributor.saüauthor Erkorkmaz, Ünal
dc.relation.journal AMERICAN JOURNAL OF THERAPEUTICS
dc.identifier.wos WOS:000372176400014
dc.identifier.doi 10.1097/MJT.0000000000000128
dc.identifier.eissn 1536-3686
dc.contributor.author Solak, Berna
dc.contributor.author Sevimli Dikicier, Bahar
dc.contributor.author Yaldız, Mahizer
dc.contributor.author Erkorkmaz, Ünal
dc.contributor.author Teoman Erdem


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