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DNA Repair Gene Polymorphism and the Risk of Mitral Chordae Tendineae Rupture

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dc.contributor.authors Yigin, AK; Vatan, MB; Akdemir, R; Aksoy, MNM; Cakar, MA; Kilic, H; Erkorkmaz, U; Karacan, K; Kaleli, S;
dc.date.accessioned 2020-02-27T07:18:21Z
dc.date.available 2020-02-27T07:18:21Z
dc.date.issued 2015
dc.identifier.citation Yigin, AK; Vatan, MB; Akdemir, R; Aksoy, MNM; Cakar, MA; Kilic, H; Erkorkmaz, U; Karacan, K; Kaleli, S; (2015). DNA Repair Gene Polymorphism and the Risk of Mitral Chordae Tendineae Rupture. DISEASE MARKERS, , -
dc.identifier.issn 0278-0240
dc.identifier.uri https://doi.org/10.1155/2015/825020
dc.identifier.uri https://hdl.handle.net/20.500.12619/65348
dc.description.abstract Polymorphisms in Lys939Gln XPC gene may diminish DNA repair capacity, eventually increasing the risk of carcinogenesis. The aim of the present study was to evaluate the significance of polymorphism Lys939Gln in XPC gene in patients with mitral chordae tendinea rupture (MCTR). Twenty-one patients with MCTR and thirty-seven age and sex matched controls were enrolled in the study. Genotyping of XPC gene Lys939Gln polymorphism was carried out using polymerase chain reaction- (PCR-) restriction fragment length polymorphism (RFLP). The frequencies of the heterozygote genotype (Lys/Gln-AC) and homozygote genotype (Gln/Gln-CC) were significantly different in MCTR as compared to control group, respectively (52.4% versus 43.2%, p = 0.049; 38.15% versus 16.2%, p = 0.018). Homozygote variant (Gln/Gln) genotype was significantly associated with increased risk of MCTR (OR = 2.059; 95% CI: 1.097-3.863; p = 0.018). Heterozygote variant (Lys/Gln) genotype was also highly significantly associated with increased risk of MCTR (OR = 1.489; 95% CI: 1.041-2.129; p = 0.049). The variant allele C was found to be significantly associated with MCTR (OR = 1.481; 95% CI: 1.101-1.992; p = 0.011). This study has demonstrated the association of XPC gene Lys939Gln polymorphism with MCTR, which is significantly associated with increased risk of MCTR.
dc.language English
dc.publisher HINDAWI LTD
dc.subject Pathology
dc.title DNA Repair Gene Polymorphism and the Risk of Mitral Chordae Tendineae Rupture
dc.type Article
dc.contributor.department Sakarya Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü
dc.contributor.saüauthor Kalaycı Yiğin, Aysel
dc.contributor.saüauthor Vatan, Mehmet Bülent
dc.contributor.saüauthor Akdemir, Ramazan
dc.contributor.saüauthor Aksoy, Muhammed Necati Murat
dc.contributor.saüauthor Çakar, Mehmet Akif
dc.contributor.saüauthor Kılıç, Harun
dc.contributor.saüauthor Erkorkmaz, Ünal
dc.contributor.saüauthor Karacan, Keziban
dc.contributor.saüauthor Kaleli, Süleyman
dc.relation.journal DISEASE MARKERS
dc.identifier.wos WOS:000364718000001
dc.identifier.doi 10.1155/2015/825020
dc.identifier.eissn 1875-8630
dc.contributor.author Kalaycı Yiğin, Aysel
dc.contributor.author Vatan, Mehmet Bülent
dc.contributor.author Akdemir, Ramazan
dc.contributor.author Aksoy, Muhammed Necati Murat
dc.contributor.author Çakar, Mehmet Akif
dc.contributor.author Kılıç, Harun
dc.contributor.author Erkorkmaz, Ünal
dc.contributor.author Karacan, Keziban
dc.contributor.author Kaleli, Süleyman


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