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Browsing Makale Koleksiyonu by Subject "Toxicology"

Now showing items 1-7 of 7

Anti-inflammatory and antioxidative properties of honey bee venom on Freund's Complete Adjuvant-induced arthritis model in rats

Abdurrahim Kocyigit; Eray Metin Guler; Kaleli, Süleyman (PERGAMON-ELSEVIER SCIENCE LTD, 2019)

The aim of this study was to assess anti-inflammatory, anti-oxidant, anti-genotoxic and immunomodulatory effects of honey bee venom (HBV) on adjuvant-induced arthritis in rats. Thirty-five rats were equally divided into a ...
BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile

Güney Eskiler, Gamze; Güney Eskiler, Gamze; Gulsah Cecener; Unal Egeli; Berrin Tunca (WILEY, 2019)

The objective of the present study was to elucidate the effect of BMN 673 (talozoparib) on BRCA1 mutant (HCC1937) and wild-type (MDA-MB-231) triple negative breast cancer (TNBC). The in vitro cytotoxicity results indicated ...
Histopathological effects of anthrax lethal factor on rat liver

Berrin Zuhal Altunkaynak; Şahin, Elvan (TAYLOR & FRANCIS LTD, 2015)

Bacillus anthracis, the causative agent of anthrax, has become an increasingly important scientific topic due to its potential role in bioterrorism. The lethal toxin (LT) of B. anthracis consists of lethal factor (LF) and ...
In vitro cytotoxic and antiproliferative effects of usnic acid on hormone-dependent breast and prostate cancer cells

Isil Ezgi Eryilmaz; Güney Eskiler, Gamze; Unal Egeli; Beste Yurdacan; Gulsah Cecener; Berrin Tunca (WILEY, 2018)

The aim of the current study was first to investigate cytotoxic activity of usnic acid (UA) on hormone-dependent breast and prostate cancer, and normal cells. Cells were treated with increasing concentrations (25 to 150 ...
Synergistic effects of hormone therapy drugs and usnic acid on hormone receptor-positive breast and prostate cancer cells

Güney Eskiler, Gamze; Güney Eskiler, Gamze; Isil Ezgi Eryilmaz; Beste Yurdacan; Unal Egeli; Gulsah Cecener; Berrin Tunca (WILEY, 2019)

The aim of this study was to investigate the combined effects of usnic acid (UA) and Tamoxifen (Tam) or Enzalutamide (Enz) on hormone receptor-positive breast and prostate cancer (BC and PC), respectively. The antiproliferative ...
The role of usnic acid-induced apoptosis and autophagy in hepatocellular carcinoma

Güney Eskiler, Gamze (SAGE PUBLICATIONS LTD, 2019)

Usnic acid (UA) is a multifunctional bioactive lichen secondary metabolite with potential anti-cancer properties. Although the promising therapeutic effects of UA have been investigated in different cancer cell lines, the ...
The susceptibility to autoxidation of erythrocytes in diabetic mice: Effects of melatonin and pentoxifylline

Şekeroğlu, Mehmet Ramazan; Zubeyir Huyut; Çokluk, Erdem; Hanefi Ozbek; Hamit Hakan Alp (WILEY, 2017)

Oxidative stress had a great importance in development of complications in diabetes. We investigated effects of melatonin and pentoxifylline in diabetic mice. Swiss albino mice (n=40) were divided into four groups: ...