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Stereoselective synthesis of new rac-quercitols containing hydroxymethyl groups as glucosidase inhibitors

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dc.contributor.authors Aydin, G; Savran, T; Baran, S; Baran, A;
dc.date.accessioned 2020-02-24T14:20:33Z
dc.date.available 2020-02-24T14:20:33Z
dc.date.issued 2018
dc.identifier.citation Aydin, G; Savran, T; Baran, S; Baran, A; (2018). Stereoselective synthesis of new rac-quercitols containing hydroxymethyl groups as glucosidase inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 28, 2560-2555
dc.identifier.issn 0960-894X
dc.identifier.uri https://doi.org/10.1016/j.bmcl.2018.05.034
dc.identifier.uri https://hdl.handle.net/20.500.12619/45241
dc.description.abstract Stereoselective and efficient synthesis of hydroxymethyl-substituted rac-quercitols (13-15) was achieved, starting from cis-furan (Kobayashi, 2008) with photooxygenation reaction, which is readily available by the reduction of cis-phtalic anhydride. alpha- and beta-Glucosidase enzyme activity of the target molecules was evaluated and good inhibitor activity was seen. One- and two-dimensional NMR spectroscopy, IR spectroscopy and X-ray crystallography were utilized in the structure characterization of products.
dc.language English
dc.publisher PERGAMON-ELSEVIER SCIENCE LTD
dc.subject Chemistry
dc.title Stereoselective synthesis of new rac-quercitols containing hydroxymethyl groups as glucosidase inhibitors
dc.type Article
dc.identifier.volume 28
dc.identifier.startpage 2555
dc.identifier.endpage 2560
dc.contributor.department Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü
dc.contributor.saüauthor Baran, Şule
dc.contributor.saüauthor Baran, Arif
dc.relation.journal BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
dc.identifier.wos WOS:000438467200046
dc.identifier.doi 10.1016/j.bmcl.2018.05.034
dc.identifier.eissn 1464-3405
dc.contributor.author Gokay Aydin
dc.contributor.author Tahir Savran
dc.contributor.author Baran, Şule
dc.contributor.author Baran, Arif


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