IN VITRO EFFECTS OF NEW GENERATION BISOXADIAZOLE SUBSTITUTED SULFONAMIDE DERIVATIVES ON HUMAN SERUM PARAOXONASE1 (PON1)

Mustafa Oguzhan Kaya; Ozcan Gulec; Arslan, Mustafa

dc.contributor.authors	Kaya, MO; Gulec, O; Arslan, M;
dc.date.accessioned	2020-02-24T14:20:26Z
dc.date.available	2020-02-24T14:20:26Z
dc.date.issued	2018
dc.identifier.citation	Kaya, MO; Gulec, O; Arslan, M; (2018). IN VITRO EFFECTS OF NEW GENERATION BISOXADIAZOLE SUBSTITUTED SULFONAMIDE DERIVATIVES ON HUMAN SERUM PARAOXONASE1 (PON1). FRESENIUS ENVIRONMENTAL BULLETIN, 27, 3358-3351
dc.identifier.issn	1018-4619
dc.identifier.uri	https://hdl.handle.net/20.500.12619/45235
dc.description.abstract	In this study, new bisoxadiazole substituted sulfonamide compounds were synthesized and in vitro inhibition effects of the compouds on purified human serum paraoxonase 1 (PON I) were investigated by using the method of Gan et al. The results showed that all the synthesized compounds inhibited the paraoxonase 1 enzyme activity. The compounds 6d and 6e were found to be most active compounds (IC50=26.5 mu M and 28.6 mu M) for PON1, respectively.
dc.language	English
dc.publisher	PARLAR SCIENTIFIC PUBLICATIONS (P S P)
dc.subject	Environmental Sciences & Ecology
dc.title	IN VITRO EFFECTS OF NEW GENERATION BISOXADIAZOLE SUBSTITUTED SULFONAMIDE DERIVATIVES ON HUMAN SERUM PARAOXONASE1 (PON1)
dc.type	Article
dc.identifier.volume	27
dc.identifier.startpage	3351
dc.identifier.endpage	3358
dc.contributor.department	Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü
dc.contributor.saüauthor	Arslan, Mustafa
dc.relation.journal	FRESENIUS ENVIRONMENTAL BULLETIN
dc.identifier.wos	WOS:000436522400016
dc.identifier.eissn	1610-2304
dc.contributor.author	Mustafa Oguzhan Kaya
dc.contributor.author	Ozcan Gulec
dc.contributor.author	Arslan, Mustafa