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Microbial hydroxylation of epiandrosterone by Aspergillus candidus

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dc.contributor.authors Yildirim, K; Kuru, A;
dc.date.accessioned 2020-02-24T14:18:46Z
dc.date.available 2020-02-24T14:18:46Z
dc.date.issued 2017
dc.identifier.citation Yildirim, K; Kuru, A; (2017). Microbial hydroxylation of epiandrosterone by Aspergillus candidus. BIOCATALYSIS AND BIOTRANSFORMATION, 35, 126-120
dc.identifier.issn 1024-2422
dc.identifier.uri https://doi.org/10.1080/10242422.2017.1289184
dc.identifier.uri https://hdl.handle.net/20.500.12619/45142
dc.description.abstract In this work, Aspergillus candidus MRC 22634 converted epiandosterone 1 into 10 hydroxylated metabolites. A. candidus has been shown to hydroxylate 1 predominantly at C-11, C-1, and C-15 with minor hydroxylations occurring at C-14 and C-7. Oxidation at C-3, reduction at C-17, and C-3 epimerization of some of the remaining substrate have also been shown. 15-Hydroxylation and C-3 epimerization of 1 by a fungus were reported for the first time. Two of the metabolites, 1,3-dihydroxy-5-androstan-17-one 4 and 15,17-dihydroxy-5-androstan-3-one 7, were identified as new compounds.
dc.language English
dc.publisher TAYLOR & FRANCIS LTD
dc.subject Biotechnology & Applied Microbiology
dc.title Microbial hydroxylation of epiandrosterone by Aspergillus candidus
dc.type Article
dc.identifier.volume 35
dc.identifier.startpage 120
dc.identifier.endpage 126
dc.contributor.department Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü
dc.contributor.saüauthor Yıldırım, Kudret
dc.contributor.saüauthor Kuru, Ali
dc.identifier.wos WOS:000398489100005
dc.identifier.doi 10.1080/10242422.2017.1289184
dc.identifier.eissn 1029-2446
dc.contributor.author Yıldırım, Kudret
dc.contributor.author Kuru, Ali

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