The biotransformation of some steroids by Aspergillus sydowii MRC 200653

Yıldırım, Kudret; Kuru, Ali

dc.contributor.authors	Yildirim, K; Kuru, A;
dc.date.accessioned	2020-02-24T14:17:41Z
dc.date.available	2020-02-24T14:17:41Z
dc.date.issued	2016
dc.identifier.citation	Yildirim, K; Kuru, A; (2016). The biotransformation of some steroids by Aspergillus sydowii MRC 200653. JOURNAL OF CHEMICAL RESEARCH, , 81-78
dc.identifier.issn	1747-5198
dc.identifier.uri	https://doi.org/10.3184/174751916X14526064507450
dc.identifier.uri	https://hdl.handle.net/20.500.12619/45071
dc.description.abstract	The incubation of testosterone, dehydroepiandrosterone, progesterone and pregnenolone with Aspergillus sydowii MRC 200653 is reported. Testosterone was mainly hydroxylated at C-6 beta and to a minor extent at C-14 alpha and C-15 alpha. Most of dehydroepiandrosterone was metabolised by a 3 beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase activity and then hydroxylated at C-6 beta. The remaining dehydroepiandrosterone was only hydroxylated at C-7 beta or C-7 alpha. Both progesterone and pregnenolone were mainly hydroxylated at C-11 alpha and C-15 beta and to a minor extent at C-6 beta and C-7 beta. The same metabolites were recovered from both biotransformations.
dc.language	English
dc.publisher	SAGE PUBLICATIONS LTD
dc.subject	Chemistry
dc.title	The biotransformation of some steroids by Aspergillus sydowii MRC 200653
dc.type	Article
dc.identifier.startpage	78
dc.identifier.endpage	81
dc.contributor.department	Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü
dc.contributor.saüauthor	Yıldırım, Kudret
dc.contributor.saüauthor	Kuru, Ali
dc.relation.journal	JOURNAL OF CHEMICAL RESEARCH
dc.identifier.wos	WOS:000371989400004
dc.identifier.doi	10.3184/174751916X14526064507450
dc.identifier.eissn	2047-6507
dc.contributor.author	Yıldırım, Kudret
dc.contributor.author	Kuru, Ali