In vitro inhibition effect of some chalcones on erythrocyte carbonic anhydrase I and II

Ceylan, Mücahit; Küçükislamoğlu, Mustafa

dc.contributor.authors	Gencer, N; Bilen, C; Demir, D; Atahan, A; Ceylan, M; Kucukislamoglu, M;
dc.date.accessioned	2020-02-24T14:15:57Z
dc.date.available	2020-02-24T14:15:57Z
dc.date.issued	2013
dc.identifier.citation	Gencer, N; Bilen, C; Demir, D; Atahan, A; Ceylan, M; Kucukislamoglu, M; (2013). In vitro inhibition effect of some chalcones on erythrocyte carbonic anhydrase I and II. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 41, 388-384
dc.identifier.issn	2169-1401
dc.identifier.uri	https://doi.org/10.3109/21691401.2012.761226
dc.identifier.uri	https://hdl.handle.net/20.500.12619/44934
dc.description.abstract	In this study, 4'-(phenylurenyl/thiourenyl) chalcones (14-25) were prepared from 4'-(phenylurenyl/thiourenyl)acetophenones and benzaldehyde derivatives by Claisen-Schmidt condensation. In vitro inhibition effects of chalcone derivatives on purified carbonic anhydrase I and carbonic anhydrase II were investigated by using the CO2 hydration method of Maren. The result showed that all the synthesized compounds inhibited the CA isoenzymes activity. 18 and 19 were found to be most active (IC50 = 25.41 m M and 23.06 mu M) for hCA I, respectively. For hCA II, 24 is the most active compound (IC50 = 14.40 mu M).
dc.language	English
dc.publisher	TAYLOR & FRANCIS LTD
dc.subject	Materials Science
dc.title	In vitro inhibition effect of some chalcones on erythrocyte carbonic anhydrase I and II
dc.type	Article
dc.identifier.volume	41
dc.identifier.startpage	384
dc.identifier.endpage	388
dc.contributor.department	Sakarya Üniversitesi/Genel Sekreterlik/Strateji Geliştirme Dairesi Başkanlığı
dc.contributor.saüauthor	Ceylan, Mücahit
dc.contributor.saüauthor	Küçükislamoğlu, Mustafa
dc.relation.journal	ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
dc.identifier.wos	WOS:000329843900005
dc.identifier.doi	10.3109/21691401.2012.761226
dc.identifier.eissn	2169-141X
dc.contributor.author	Ceylan, Mücahit
dc.contributor.author	Küçükislamoğlu, Mustafa