alpha-Bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: Structure-activity relationship

Arabacı, Gülnur; T Yi; H Fu; Me Porter; Kd Beebe; Dh Pei

dc.contributor.authors	Arabaci, G; Yi, T; Fu, H; Porter, ME; Beebe, KD; Pei, DH;
dc.date.accessioned	2020-02-24T14:15:39Z
dc.date.available	2020-02-24T14:15:39Z
dc.date.issued	2002
dc.identifier.citation	Arabaci, G; Yi, T; Fu, H; Porter, ME; Beebe, KD; Pei, DH; (2002). alpha-Bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: Structure-activity relationship. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 12, 3050-3047
dc.identifier.issn	0960-894X
dc.identifier.uri	https://hdl.handle.net/20.500.12619/44905
dc.identifier.uri	https://doi.org/10.1016/S0960-894X(02)00681-9
dc.description.abstract	A series of α-haloacetophenone derivatives was tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B. The results show that the bromides are much more potent than the corresponding chlorides, whereas the phenyl ring is remarkably tolerant to modifications. Derivatization of the phenyl ring with a tripeptide Gly-Glu-Glu resulted in a potent, selective inhibitor against PTP1B. A series of α-haloacetophenone derivatives was tested against SHP-1 and PTB1B to define the SAR.
dc.language	English
dc.publisher	PERGAMON-ELSEVIER SCIENCE LTD
dc.title	alpha-Bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: Structure-activity relationship
dc.type	Article
dc.identifier.volume	12
dc.identifier.startpage	3047
dc.identifier.endpage	3050
dc.contributor.department	Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü
dc.contributor.saüauthor	Arabacı, Gülnur
dc.relation.journal	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
dc.identifier.wos	WOS:000178693100005
dc.contributor.author	Arabacı, Gülnur
dc.contributor.author	T Yi
dc.contributor.author	H Fu
dc.contributor.author	Me Porter
dc.contributor.author	Kd Beebe
dc.contributor.author	Dh Pei