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Browsing Makale Koleksiyonu by Author

Browsing Makale Koleksiyonu by Author "Gulfen, M; Ozdemir, A; Lin, JL; Chen, CH;"

Now showing items 1-4 of 4

ESI-MS measurements for the equilibrium constants of copper(II)-insulin complexes

Gülfen, Mustafa; Özdemir, Abdil; Jung-Lee Lin; Chung-Hsuan Chen (ELSEVIER SCIENCE BV, 2018)

Trace elements regulate many biological reactions in the body. Copper(II) is known as one of trace elements and capable of binding to proteins. Insulin is a blood glucose-lowering peptide hormone and it is secreted by the ...
Investigation of manganese(II)-insulin complexes using electrospray ionization mass spectrometry

Gülfen, Mustafa; Özdemir, Abdil; Jung-Lee Lin; Chung-Hsuan Chen (ELSEVIER SCIENCE BV, 2018)

Manganese is a trace element in human nutrition. It is involved in many enzymes, proteins and biological activities. Mn(II) ion has the capable of binding to protein or peptides. Insulin is a blood glucose-lowering peptide ...
Investigation of non-covalent complexations of Ca(II) and Mg(II) ions with insulin by using electrospray ionization mass spectrometry

Gülfen, Mustafa; Özdemir, Abdil; Jung-Lee Lin; Chung-Hsuan Chen (WILEY-BLACKWELL, 2016)

ConclusionsThe binding equilibrium constants of Ca(II)- and Mg(II)-insulin non-covalent complexes have been determined successfully by ESI-MS. Ca(II) and Mg(II) ions are involved in the insulin secretion by forming ...
Quantifying Na(I)-insulin and K(I)-insulin non-covalent complexes by ESI-MS method and calculation of their equilibrium constants

Gülfen, Mustafa; Özdemir, Abdil; Jung-Lee Lin; Chung-Hsuan Chen (ELSEVIER SCIENCE BV, 2017)

In this study, the dissociation and formation equilibrium constants of Na(l)-insulin and K(I)-insulin complexes have been calculated after the quantifying them on ESI mass spectrometer. The ESI-MS spectra of the complexes ...