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Highly enantioselective reduction of acetophenone by locally isolated Alternaria alternata using ram horn peptone

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dc.contributor.authors Kurbanoglu, EB; Zilbeyaz, K; Kurbanoglu, NI; Taskin, M;
dc.date.accessioned 2020-02-24T13:29:04Z
dc.date.available 2020-02-24T13:29:04Z
dc.date.issued 2007
dc.identifier.citation Kurbanoglu, EB; Zilbeyaz, K; Kurbanoglu, NI; Taskin, M; (2007). Highly enantioselective reduction of acetophenone by locally isolated Alternaria alternata using ram horn peptone. TETRAHEDRON-ASYMMETRY, 18, 1532-1529
dc.identifier.issn 0957-4166
dc.identifier.uri https://doi.org/10.1016/j.tetasy.2007.06.013
dc.identifier.uri https://hdl.handle.net/20.500.12619/44198
dc.description.abstract Enantiomerically pure compounds are important building blocks in the synthesis of natural products. In this study, the reduction of acetophenone to the (S)-isomer of 1-phenylalcohol with a high enantiomeric excess (ee) by locally isolated Alternaria alternata using ram horn peptone (RHP) was investigated. Ten strains of A. alternata were isolated from different plant samples. These isolates were evaluated for the reduction of acetophenone (ACP) to 1-phenylethanot (PEA). Glucose, yeast extract and RHP in a shake flask and fermenter for growth of A. alternata cultures were used. A. alternata EBK-4 isolate was found to be an effective biocatalyst for the enantiomeric bioreduction of acetophenone. Conversions of up to 100%) with excellent enantiomeric excesses (>99%) were obtained. Production of PEA was achieved via a fermenter. The yield was calculated as 86%. This is the first report on the enantioselective reduction of ACP by A. alternata using ram horn peptone from waste material. (C) 2007 Elsevier Ltd. All rights reserved.
dc.language English
dc.publisher PERGAMON-ELSEVIER SCIENCE LTD
dc.subject Chemistry
dc.title Highly enantioselective reduction of acetophenone by locally isolated Alternaria alternata using ram horn peptone
dc.type Article
dc.identifier.volume 18
dc.identifier.startpage 1529
dc.identifier.endpage 1532
dc.contributor.department Sakarya Üniversitesi/Eğitim Fakültesi/Matematik Ve Fen Bilimleri Eğitimi Bölümü
dc.contributor.saüauthor Kurbanoğlu, Namudar İzzet
dc.contributor.saüauthor Taşkın, Mehmet Fatih
dc.relation.journal TETRAHEDRON-ASYMMETRY
dc.identifier.wos WOS:000248966600004
dc.identifier.doi 10.1016/j.tetasy.2007.06.013
dc.contributor.author Kurbanoğlu, Namudar İzzet
dc.contributor.author Taşkın, Mehmet Fatih


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