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The role of n-butyl-2-cyanoacrylate in the repair of traumatic diaphragmatic injuries

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dc.contributor.authors Bas, G; Ozkan, OV; Alimoglu, O; Eryilmaz, R; Sahin, M; Okan, I; Cevikbas, U;
dc.date.accessioned 2020-01-14T08:17:07Z
dc.date.available 2020-01-14T08:17:07Z
dc.date.issued 2015
dc.identifier.citation Bas, G; Ozkan, OV; Alimoglu, O; Eryilmaz, R; Sahin, M; Okan, I; Cevikbas, U; (2015). The role of n-butyl-2-cyanoacrylate in the repair of traumatic diaphragmatic injuries. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 8, 5882-5876
dc.identifier.issn 1940-5901
dc.identifier.uri https://hdl.handle.net/20.500.12619/3379
dc.identifier.uri https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483802/pdf/ijcem0008-5876.pdf
dc.description.abstract Diaphragmatic injuries either by blunt or penetrating trauma require prompt surgical intervention and are often exigent to repair. N-butyl-2-cyanoacrylate (n-butyl-2-CA) is a tissue adhesive which has gained wide application in many areas of surgery including emergency. To repair the extensive injuries of the diaphragm it may be necessary the use of synthetic mesh by fixing it with sutures or staples. The use of tissue adhesives may circumvent the potential problems associated with mesh fixation. This study aimed to evaluate the efficacy and safety of tissue adhesives usage for mesh fixation in diaphragmatic injury repair. Twenty-four rats were divided into 3 groups each of them containing 8 rats. A 1- cm diaphragmatic defect was created in all rats. The defect was repaired by polypropylene suture in Group I, by mesh fixed with sutures in group II and by mesh fixed with n-butyl-2-CA in group III. The rats were sacrificed after 1 month. The episode of hernia and the adhesions were assessed by adhesion density score. Also, the abscess and inflammation in the repaired tissue were evaluated microscopically. The Kruskal-Wallis test was performed for the histopathological analysis. No diaphragmatic hernia was detected in any group. While Group III had higher adhesion density scores than group I (P: 0.027), there were no differences between group III and II (P: 0.317) and group II and I (P = 0.095) regarding adhesion density scores. The inflammation grade was higher in group III than group I and II (P < 0.001) and was higher in group II than group I (P < 0.05). There was no differences between each groups, concerning microabcsess formation (P > 0.05). Repair of traumatic diaphragmatic injury in penetrating wound, with polypropylene mesh fixed by n-butyl-2-CA in rats appears to be as efficacious and safe as conventional methods in early period. However, further experimental and clinical study are needed to compare the long-term results of adhesive mesh repair with those of the traditional sutured techniques.
dc.language English
dc.publisher E-CENTURY PUBLISHING CORP
dc.subject Research & Experimental Medicine
dc.title The role of n-butyl-2-cyanoacrylate in the repair of traumatic diaphragmatic injuries
dc.type Article
dc.identifier.volume 8
dc.identifier.startpage 5876
dc.identifier.endpage 5882
dc.contributor.department Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Sosyoloji Bölümü
dc.contributor.saüauthor Şahin, Mehmet Murat
dc.relation.journal INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
dc.identifier.wos WOS:000358377700131
dc.contributor.author Gurhan Bas
dc.contributor.author Orhan Veli Ozkan
dc.contributor.author Orhan Alimoglu
dc.contributor.author Ramazan Eryilmaz
dc.contributor.author Şahin, Mehmet Murat
dc.contributor.author Ismail Okan
dc.contributor.author Ugur Cevikbas


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