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Early cardiac abnormalities and serum N-terminal pro B-type natriuretic peptide levels in obese children

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dc.contributor.authors Battal, F; Ermis, B; Aktop, Z; Can, M; Demirel, F
dc.date.accessioned 2020-01-14T07:25:14Z
dc.date.available 2020-01-14T07:25:14Z
dc.date.issued 2011
dc.identifier.citation Battal, F; Ermis, B; Aktop, Z; Can, M; Demirel, F (2011). Early cardiac abnormalities and serum N-terminal pro B-type natriuretic peptide levels in obese children. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 24, 726-723
dc.identifier.issn 0334-018X
dc.identifier.uri https://hdl.handle.net/20.500.12619/3338
dc.identifier.uri https://doi.org/10.1515/JPEM.2011.285
dc.description.abstract Objective: The aim of this study was to evaluate early cardiac abnormalities in obese children by the conventional echocardiography and to verify whether N-terminal pro B-type natriuretic peptide (NT-proBNP) differ between obese and healthy children. Methods: We started this study with 68 obese children and 35 healthy controls matched for age and sex. Body mass index (BMI) was calculated. Children with a BMI >= 95th percentile were considered obese. Thirty children in the obese group were also diagnosed with metabolic syndrome, according to the International Diabetes Federation criteria. Standard echocardiographic study was performed on each patient and control subject. Diastolic filling parameters were evaluated using pulsed-wave tissue Doppler method. Blood samples were taken at 8 a. m. to study blood biochemistry tests, including insulin, lipids, glucose, and NT-proBNP. Serum NT-proBNP levels were measured by a solid-phase, enzyme-labeled chemiluminescent immunometric assay. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Children with HOMA-IR >3.16 were considered insulin-resistant. Results: There were diastolic filling abnormalities in obese children, as shown by a decreased mitral valve early filling (E) wave/late filling (A) ratio and a prolongation in E-wave deceleration time. The levels of NT-proBNP were not statistically different among the groups. The levels of NT-proBNP were not different between obese children with and without metabolic syndrome, those with and without hypertension, and those with and without insulin resistance, respectively. Conclusion: Although there were diastolic filling abnormalities in obese children, their NT-proBNP levels were not different from healthy controls. It seems that there is no diagnostic value in NT-proBNP levels between obese children and healthy controls
dc.language English
dc.publisher WALTER DE GRUYTER GMBH
dc.title Early cardiac abnormalities and serum N-terminal pro B-type natriuretic peptide levels in obese children
dc.type Article
dc.identifier.volume 24
dc.identifier.startpage 723
dc.identifier.endpage 726
dc.contributor.department Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü
dc.contributor.saüauthor Ermiş, Bahri
dc.contributor.saüauthor Can, Muhammed Zahit
dc.relation.journal JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
dc.identifier.wos WOS:000297470000019
dc.identifier.doi 10.1515/JPEM.2011.285
dc.identifier.eissn 2191-0251
dc.contributor.author Ermiş, Bahri
dc.contributor.author Can, Muhammed Zahit


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