Stereoselective synthesis of new rac-quercitols containing hydroxymethyl groups as glucosidase inhibitors

Gokay Aydin; Tahir Savran; Baran, Şule; Baran, Arif

dc.contributor.authors	Aydin, G; Savran, T; Baran, S; Baran, A;
dc.date.accessioned	2020-01-20T09:03:57Z
dc.date.available	2020-01-20T09:03:57Z
dc.date.issued	2018
dc.identifier.citation	Aydin, G; Savran, T; Baran, S; Baran, A; (2018). Stereoselective synthesis of new rac-quercitols containing hydroxymethyl groups as glucosidase inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 28, 2560-2555
dc.identifier.issn	0960-894X
dc.identifier.uri	https://hdl.handle.net/20.500.12619/33343
dc.identifier.uri	https://doi.org/10.1016/j.bmcl.2018.05.034
dc.description.abstract	Stereoselective and efficient synthesis of hydroxymethyl-substituted rac-quercitols (13-15) was achieved, starting from cis-furan (Kobayashi, 2008) with photooxygenation reaction, which is readily available by the reduction of cis-phtalic anhydride. alpha- and beta-Glucosidase enzyme activity of the target molecules was evaluated and good inhibitor activity was seen. One- and two-dimensional NMR spectroscopy, IR spectroscopy and X-ray crystallography were utilized in the structure characterization of products.
dc.language	English
dc.publisher	PERGAMON-ELSEVIER SCIENCE LTD
dc.subject	Chemistry
dc.title	Stereoselective synthesis of new rac-quercitols containing hydroxymethyl groups as glucosidase inhibitors
dc.type	Article
dc.identifier.volume	28
dc.identifier.startpage	2555
dc.identifier.endpage	2560
dc.contributor.department	Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü
dc.contributor.saüauthor	Baran, Şule
dc.contributor.saüauthor	Baran, Arif
dc.relation.journal	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
dc.identifier.wos	WOS:000438467200046
dc.identifier.doi	10.1016/j.bmcl.2018.05.034
dc.identifier.eissn	1464-3405
dc.contributor.author	Gokay Aydin
dc.contributor.author	Tahir Savran
dc.contributor.author	Baran, Şule
dc.contributor.author	Baran, Arif