Browsing Fen-Edebiyat Fakültesi by Author "Umit Muhammet Kocyigit"

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SAR Evaluation of Disubstituted Tacrine Analogues as Promising Cholinesterase and Carbonic Anhydrase Inhibitors

Salih Okten; Makbule Ekiz; Tutar, Ahmet; Burcu Butun; Umit Muhammet Kocyigit; Gulacti Topcu; Ilhami Gulcin (ASSOC PHARMACEUTICAL TEACHERS INDIA, 2019)

Background: The inhibition of both hydrolysis products of acetylcholine (ACh), Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE), is essential for successful treatment of Alzhemier patients. Objectives: This ...
Synthesis, characterization, crystal structures, theoretical calculations and biological evaluations of novel substituted tacrine derivatives as cholinesterase and carbonic anhydrase enzymes inhibitors

Salih Okten; Makbule Ekiz; Umit Muhammet Kocyigit; Tutar, Ahmet; Çelik, İsmail; Mehmet Akkurt; Faik Gokalp; Parham Taslimi; Ilhami Gulcin (ELSEVIER SCIENCE BV, 2019)

The six and seven hydrocycle membered disilylanilino acridine (tacrine) analogues (9-11) were synthesized by one-pot procedures. The structures of novel silyl tacrine derivatives were characterized by NMR spectroscopy, ...