Browsing Fen-Edebiyat Fakültesi by Author "Ekiz, M; Tutar, A; Okten, S;"

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Convenient synthesis of disubstituted tacrine derivatives via electrophilic and copper induced reactions

Makbule Ekiz; Tutar, Ahmet; Salih Okten (PERGAMON-ELSEVIER SCIENCE LTD, 2016)

The bromination of 2-aminobenzonitrile (2) with molecular bromine (2 equiv) furnished 2-amino-3,5-dibromobenzonitrile (7) in 98% yield. One-pot syntheses are described for dibromotacrine derivatives (6,14-18) utilizing ...