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Synthesis and theoretical calculations of carbazole substituted chalcone urea derivatives and studies their polyphenol oxidase enzyme activity

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dc.contributor.authors Nixha, AR; Arslan, M; Atalay, Y; Gencer, N; Ergun, A; Arslan, O;
dc.date.accessioned 2020-01-20T08:02:07Z
dc.date.available 2020-01-20T08:02:07Z
dc.date.issued 2013
dc.identifier.citation Nixha, AR; Arslan, M; Atalay, Y; Gencer, N; Ergun, A; Arslan, O; (2013). Synthesis and theoretical calculations of carbazole substituted chalcone urea derivatives and studies their polyphenol oxidase enzyme activity. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 28, 815-808
dc.identifier.issn 1475-6366
dc.identifier.uri https://hdl.handle.net/20.500.12619/32084
dc.identifier.uri https://doi.org/10.3109/14756366.2012.688040
dc.description.abstract Synthesis of carbazole substituted chalcone urea derivatives and their polyphenol oxidase enzyme activity effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-l-tyrosine-p-aminobenzoic acid. The results showed that most of the compounds (3,4,5a,5d-h) inhibited and some of them (5c,5i-l) activated the tyrosinase enzyme activity. The molecular calculations were performed using Gaussian software for the synthesized compounds to explain the experimental results.
dc.language English
dc.publisher TAYLOR & FRANCIS LTD
dc.subject Pharmacology & Pharmacy
dc.title Synthesis and theoretical calculations of carbazole substituted chalcone urea derivatives and studies their polyphenol oxidase enzyme activity
dc.type Article
dc.identifier.volume 28
dc.identifier.startpage 808
dc.identifier.endpage 815
dc.contributor.department Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü
dc.contributor.saüauthor Arslan, Mustafa
dc.contributor.saüauthor Atalay, Yusuf
dc.relation.journal JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
dc.identifier.wos WOS:000321693400021
dc.identifier.doi 10.3109/14756366.2012.688040
dc.identifier.eissn 1475-6374
dc.contributor.author Arslan, Mustafa
dc.contributor.author Atalay, Yusuf


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