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Browsing Kimya / Chemistry by Author "Makbule Ekiz"

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Convenient synthesis of disubstituted tacrine derivatives via electrophilic and copper induced reactions

Makbule Ekiz; Tutar, Ahmet; Salih Okten (PERGAMON-ELSEVIER SCIENCE LTD, 2016)

The bromination of 2-aminobenzonitrile (2) with molecular bromine (2 equiv) furnished 2-amino-3,5-dibromobenzonitrile (7) in 98% yield. One-pot syntheses are described for dibromotacrine derivatives (6,14-18) utilizing ...
SAR Evaluation of Disubstituted Tacrine Analogues as Promising Cholinesterase and Carbonic Anhydrase Inhibitors

Salih Okten; Makbule Ekiz; Tutar, Ahmet; Burcu Butun; Umit Muhammet Kocyigit; Gulacti Topcu; Ilhami Gulcin (ASSOC PHARMACEUTICAL TEACHERS INDIA, 2019)

Background: The inhibition of both hydrolysis products of acetylcholine (ACh), Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE), is essential for successful treatment of Alzhemier patients. Objectives: This ...
Synthesis, characterization, and SAR of arylated indenoquinoline-based cholinesterase and carbonic anhydrase inhibitors

Makbule Ekiz; Tutar, Ahmet; Salih Okten; Burcu Butun; Umit M. Kocyigit; Parham Taslimi; Guelacti Topcu (WILEY-V C H VERLAG GMBH, 2018)

We report the synthesis of bromoindenoquinolines (15a-f) by Friedlander reactions in low yields (13-50%) and the conversion of the corresponding phenyl-substituted indenoquinoline derivatives 16-21 in high yields (80-96%) ...
Synthesis, characterization, crystal structures, theoretical calculations and biological evaluations of novel substituted tacrine derivatives as cholinesterase and carbonic anhydrase enzymes inhibitors

Salih Okten; Makbule Ekiz; Umit Muhammet Kocyigit; Tutar, Ahmet; Çelik, İsmail; Mehmet Akkurt; Faik Gokalp; Parham Taslimi; Ilhami Gulcin (ELSEVIER SCIENCE BV, 2019)

The six and seven hydrocycle membered disilylanilino acridine (tacrine) analogues (9-11) were synthesized by one-pot procedures. The structures of novel silyl tacrine derivatives were characterized by NMR spectroscopy, ...