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Browsing Kimya / Chemistry by Author "Chung-Hsuan Chen"

Now showing items 1-8 of 8

A Comparative Study for Sonic Spray and Electrospray Ionization Methods to Determine Noncovalent Protein-Ligand Interactions

Özdemir, Abdil; Gülfen, Mustafa; Jung-Lee Lin; Chung-Hsuan Chen (TAYLOR & FRANCIS INC, 2019)

A comparative study between sonic spray ionization (SSI) and electrospray ionization (ESI) is reported for cluster formation of proteins and ligands. For the observation of cluster formation, the interactions were not ...
A quadrupole ion trap mass spectrometer for dry microparticle analysis

Özdemir, Abdil; Jung-Lee Lin; Gülfen, Mustafa; Chun-Jen Hsiao; Chung-Hsuan Chen (ROYAL SOC CHEMISTRY, 2019)

In this work, we report a new design of a charge detection quadrupole ion trap mass spectrometer (QIT-MS) for the analysis of micro-sized dry inorganic and bioparticles including red blood cells (RBCs) and different sizes ...
Analysis of Saccharides by the Addition of Amino Acids

Özdemir, Abdil; Jung-Lee Lin; Kent J. Gillig; Gülfen, Mustafa; Chung-Hsuan Chen (SPRINGER, 2016)

In this work, we present the detection sensitivity improvement of electrospray ionization (ESI) mass spectrometry of neutral saccharides in a positive ion mode by the addition of various amino acids. Saccharides of a broad ...
ESI MS for Microsized Bioparticles

Özdemir, Abdil; Jung-Lee Lin; Gülfen, Mustafa; Szu-Hsueh Lai; Chun-Jen Hsiao; Nelson G. Chen; Chung-Hsuan Chen (AMER CHEMICAL SOC, 2017)

An ESI ion trap mass spectrometer was designed for high-throughput and rapid mass analysis of large bioparticles. Mass calibration of the instrument was performed using commercially available polystyrene (PS) microparticles ...
ESI-MS measurements for the equilibrium constants of copper(II)-insulin complexes

Gülfen, Mustafa; Özdemir, Abdil; Jung-Lee Lin; Chung-Hsuan Chen (ELSEVIER SCIENCE BV, 2018)

Trace elements regulate many biological reactions in the body. Copper(II) is known as one of trace elements and capable of binding to proteins. Insulin is a blood glucose-lowering peptide hormone and it is secreted by the ...
Investigation of manganese(II)-insulin complexes using electrospray ionization mass spectrometry

Gülfen, Mustafa; Özdemir, Abdil; Jung-Lee Lin; Chung-Hsuan Chen (ELSEVIER SCIENCE BV, 2018)

Manganese is a trace element in human nutrition. It is involved in many enzymes, proteins and biological activities. Mn(II) ion has the capable of binding to protein or peptides. Insulin is a blood glucose-lowering peptide ...
Investigation of non-covalent complexations of Ca(II) and Mg(II) ions with insulin by using electrospray ionization mass spectrometry

Gülfen, Mustafa; Özdemir, Abdil; Jung-Lee Lin; Chung-Hsuan Chen (WILEY-BLACKWELL, 2016)

ConclusionsThe binding equilibrium constants of Ca(II)- and Mg(II)-insulin non-covalent complexes have been determined successfully by ESI-MS. Ca(II) and Mg(II) ions are involved in the insulin secretion by forming ...
Quantifying Na(I)-insulin and K(I)-insulin non-covalent complexes by ESI-MS method and calculation of their equilibrium constants

Gülfen, Mustafa; Özdemir, Abdil; Jung-Lee Lin; Chung-Hsuan Chen (ELSEVIER SCIENCE BV, 2017)

In this study, the dissociation and formation equilibrium constants of Na(l)-insulin and K(I)-insulin complexes have been calculated after the quantifying them on ESI mass spectrometer. The ESI-MS spectra of the complexes ...