The protective effects of hesperidin pretreatment on kidney and remote organs against renal ischemia-reperfusion injury

Abstract

OBJECTIVE: As an antioxidant and anti-inflammatory agent, Hesperidin was in-vestigated to prove whether it prevents damage to the kidney and lung tissues of rats undergo-ing renal ischemia-reperfusion injury.MATERIALS AND METHODS: Four groups of rats were set, including eight subjects each as Group 1 (control), Group 2-RIR (renal isch-emia reperfusion), Groups 3 and 4 as pretreat-ment groups (50 HES, 100 HES).RESULTS: According to our results, Hesperi-din pretreatment improved the biochemical and histopathological parameters in kidney and lung tissues of rats with ischemia-reperfusion injury. Besides, a 100 mg/kg dose of Hesperidin was found to be more beneficial to the rats than 50 mg/kg.CONCLUSIONS: The study suggests that Hesperidin is protective against renal and lung tissues of rats that underwent ischemia-reper-fusion injury.