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Browsing by Subject "IN-VITRO"

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Chalcone-based dipolar cycloaddition of novel heteroaromatic compounds: Their anticancer examination

Kinali, M; Çol, S; Çoban, CÇ; Türk, M; Aydin, G; Emirik, M; Baran, A (2023)

In this study, new chalcone-isoxazole-based hybrid derivatives (12, 13, 18, and 21) and chalcone-triazole hybrid molecules (26) were synthesized using the click chemistry approach. Among these hybrid molecules, 12, 13, 21, ...
Novel benzoic acid derivatives: Synthesis and biological evaluation as multitarget acetylcholinesterase and carbonic anhydrase inhibitors

Kalayci, Muharrem; Turkes, Cuneyt; Arslan, Mustafa; Demir, Yeliz; Beydemir, Sukru (WILEY-V C H VERLAG GMBH, 2021)

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia, memory impairment, cognitive dysfunction, and speech impairment. The utility of cholinergic replacement by acetylcholinesterase (AChE) ...
Novel potential metabolic enzymes inhibitor, photosensitizer and antibacterial agents based on water-soluble phthalocyanine bearing imidazole derivative

Gunsel, Armagan; Taslimi, Parham; Atmaca, Goknur Yasta; Bilgicli, Ahmet T.; Piskin, Hasan; Ceylan, Yusuf; Erdogmus, Ali; Yarasir, M. Nilufer; Gulcin, Ilhami (ELSEVIER, 2021)

In this work, we have reported on the synthesis and characterization of water-soluble hydrochloride forms (2a-4a) based on novel peripherally [M = metal-free (2), zinc (II) (3), gallium (III) chloride (4)] phthalocyanines ...
Sulfonamides incorporating ketene N,S-acetal bioisosteres as potent carbonic anhydrase and acetylcholinesterase inhibitors

Istrefi, Qendresa; Turkes, Cuneyt; Arslan, Mustafa; Demir, Yeliz; Nixha, Arleta R.; Beydemir, Sukru; Kufrevioglu, Omer, I (WILEY-V C H VERLAG GMBH, 2020)

In this study, 15 novel compounds in a series of sulfonamide-based ketenes (7a-o) were synthesized and characterized using Fourier-transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and mass spectrometry. ...
Synthesis of water soluble tetra-substituted phthalocyanines: Investigation of DNA cleavage, cytotoxic effects and metabolic enzymes inhibition

Gunsel, Armagan; Bilgicli, Ahmet T.; Barut, Burak; Taslimi, Parham; Ozel, Arzu; Biyiklioglu, Zekeriya; Yarasir, M. Nilufer; Gulcin, Ilhami (ELSEVIER, 2020)

In this study, we have reported the synthesis and characterization of 4-(sodium 2-mercaptoethane sulfonate) phthalonitrile (1) as ligand and its water-soluble phthalocyanine compounds [M = 2H (2), Zn(II) (3), Ga(III)Cl ...
Synthesis, characterization, photo-physicochemical and biological properties of water-soluble tetra-substituted phthalocyanines: Antidiabetic, anticancer and anticholinergic potentials

Gunsel, Armagan; Atmaca, Goknur Yasa; Taslimi, Parham; Bilgicli, Ahmet T.; Gulcin, Ilhami; Erdogmus, Ali; Yarasir, M. Nilufer (ELSEVIER SCIENCE SA, 2020)

In this study, we have reported on the synthesis and characterization of water-soluble phthalocyanines [M = 2H (2), Zn(II) (3), Ga(III)Cl (4)], containing sodium 2-mercaptoethanesulfonate substituents at the non-peripheral ...