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Browsing by Subject "Carbonic anhydrase"

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Cytotoxic effect, enzyme inhibition, and in silico studies of some novel N-substituted sulfonyl amides incorporating 1,3,4-oxadiazol structural motif

Gulec, Ozcan; Turkes, Cuneyt; Arslan, Mustafa; Demir, Yeliz; Yeni, Yesim; Hacimuftuoglu, Ahmet; Ereminsoy, Ergun; Kufrevioglu, Omer Irfan; Beydemir, Sukru (SPRINGER, 2022)

The acetylcholinesterase and carbonic anhydrase inhibitors (AChEIs and hCAIs) remain key therapeutic agents for many bioactivities such as anti-Alzheimer and antiobesity antiepileptic, anticancer, antiinfective, antiglaucoma, ...
Discovery of novel benzenesulfonamides incorporating 1,2,3-triazole scaffold as carbonic anhydrase I, II, IX, and XII inhibitors

Buza A.; Türkeş C.; Arslan M.; Demir Y.; Dincer B.; Nixha A.R.; Beydemir S. (2023)

Sulfonamides are among the most promising potential inhibitors for carbonic anhydrases (CAs), which are pharmaceutically relevant targets for treating several disease conditions. Herein, a series of benzenesulfonamides ...
Exploration of 1,2,3-triazole linked benzenesulfonamide derivatives as isoform selective inhibitors of human carbonic anhydrase

Kakakhan C.; Türkeş C.; Güleç Ö.; Demir Y.; Arslan M.; Özkemahlı G.; Beydemir (2023)

A novel series of 1,2,3-triazole benzenesulfonamide substituted 1,3-dioxoisoindolin-5-carboxylate (7a-l) inhibitors of human ?-carbonic anhydrase (hCA) was designed using a tail approach. The design method relies on the ...
Novel beta-lactam substituted benzenesulfonamides: in vitro enzyme inhibition, cytotoxic activity and in silico interactions

Gulec, Ozcan; Turkes, Cuneyt; Arslan, Mustafa; Demir, Yeliz; Dincer, Busra; Ece, Abdulilah; Beydemir, Sukru (TAYLOR & FRANCIS INC, 2023)

In this study, a library of twelve beta-lactam-substituted benzenesulfonamides (5a-l) was synthesized using the tail-approach method. The compounds were characterized using IR, H-1 NMR, C-13 NMR and elemental analysis ...
Synthesis, characterization, evaluation of metabolic enzyme inhibitors and in silico studies of thymol based 2-amino thiol and sulfonic acid compounds

Bora, Rifat Emin; Bilgicli, Hayriye Genc; Uc, Eda Mehtap; Alagoz, Mehmet Abdullah; Zengin, Mustafa; Gulcin, Ilhami (2022)

Eight new aminothiols (4a-g and 5) and three new sulfonic acid derivatives (6a-c) were synthesized, and their structures were characterized. Inhibitory effects of the obtained compounds on carbonic anhydrase I and II ...