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The evaluation of the genotoxicity of two food preservatives: Sodium benzoate and potassium benzoate

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dc.contributor.authors Zengin, N; Yuzbasioglu, D; Unal, F; Yilmaz, S; Aksoy, H
dc.date.accessioned 2020-10-16T11:39:31Z
dc.date.available 2020-10-16T11:39:31Z
dc.date.issued 2011
dc.identifier.citation Zengin, N; Yuzbasioglu, D; Unal, F; Yilmaz, S; Aksoy, H (2011). The evaluation of the genotoxicity of two food preservatives: Sodium benzoate and potassium benzoate. FOOD AND CHEMICAL TOXICOLOGY, 49, 769-763
dc.identifier.issn 0278-6915
dc.identifier.uri https://doi.org/10.1016/j.fct.2010.11.040
dc.identifier.uri https://hdl.handle.net/20.500.12619/69971
dc.description.abstract In this study, the genotoxic effects of sodium benzoate (SB) and potassium benzoate (PB) were investigated in cultured human peripheral lymphocytes using chromosomal aberrations (CA), sister chromatid exchange (SCE), and micronuclei (MN). The level of nuclear DNA damage of SB and PB were also evaluated using the comet assay. The lymphocytes were incubated with different concentrations of SB (6.25, 12.5, 25, 50, and 100 mu g/ml) and PB (62.5, 125, 250, 500, and 1000 mu g/ml). A significant increase was observed in CA. SCE, and MN, in almost all treatments compared to negative controls. SB and PB significantly decreased the mitotic index (MI) in all the treatments, compared to the negative controls. However, neither of the additives affected the replication index (RI). Although SB significantly increased DNA damage, PB did not cause a significant increase in DNA damage. The present results indicate that SB and PB are clastogenic, mutagenic and cytotoxic to human lymphocytes in vitro. (C) 2010 Elsevier Ltd. All rights reserved.
dc.language English
dc.publisher PERGAMON-ELSEVIER SCIENCE LTD
dc.title The evaluation of the genotoxicity of two food preservatives: Sodium benzoate and potassium benzoate
dc.type Article
dc.identifier.volume 49
dc.identifier.startpage 763
dc.identifier.endpage 769
dc.contributor.department Sakarya Üniversitesi/İlahiyat Fakültesi/İslam Tarihi Ve Sanatları Bölümü
dc.contributor.saüauthor Yılmaz, Saim
dc.contributor.saüauthor Aksoy, Hüseyin
dc.contributor.saüauthor Yılmaz, Şenol
dc.relation.journal FOOD AND CHEMICAL TOXICOLOGY
dc.identifier.wos WOS:000289136100008
dc.identifier.doi 10.1016/j.fct.2010.11.040
dc.identifier.eissn 1873-6351
dc.contributor.author Yılmaz, Saim
dc.contributor.author Aksoy, Hüseyin
dc.contributor.author Yılmaz, Şenol


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